• Publications
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2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up,
During the past decade, catheter ablation of atrial fibrillation (AF) has evolved rapidly from an investigational procedure to its current status as a commonly performed ablation procedure in manyExpand
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HRS/EHRA/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm
Hugh Calkins, MD, FHRS; Josep Brugada, MD, FESC; Douglas L. Packer, MD, FHRS; Riccardo Cappato, MD, FESC; Shih-Ann Chen, MD, FHRS; Harry J. G. Crijns, MD, FESC; Ralph J. Damiano, Jr., MD; D. WynExpand
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Electrical alternans and vulnerability to ventricular arrhythmias.
BACKGROUND Although electrical alternans (alternating amplitude from beat to beat on the electrocardiogram) has been associated with ventricular arrhythmias in many clinical settings, its physiologicExpand
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Cryoballoon ablation of pulmonary veins for paroxysmal atrial fibrillation: first results of the North American Arctic Front (STOP AF) pivotal trial.
OBJECTIVES This study sought to assess the safety and effectiveness of a novel cryoballoon ablation technology designed to achieve single-delivery pulmonary vein (PV) isolation. BACKGROUND StandardExpand
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Electrical alternans and cardiac electrical instability.
We investigated the relationship between electrical alternans and cardiac electrical stability in a series of 20 dog experiments and in a pilot clinical study. Electrical alternans was detected inExpand
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The QT interval.
The effects of disease states and therapeutic drugs on the QT interval have been extensively studied in an attempt to understand the relationship between QT and the risk of torsade de pointes andExpand
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Drugs That Induce Repolarization Abnormalities Cause Bradycardia in Zebrafish
Background—Drug-induced QT prolongation and torsades de pointes remain significant and often unpredictable clinical problems. Current in vitro preclinical assays are limited by biological simplicity,Expand
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Drug‐Induced Torsades de Pointes and Implications for Drug Development
Torsades de pointes is a potentially lethal arrhythmia that occasionally appears as an adverse effect of pharmacotherapy. Recently developed understanding of the underlying electrophysiology allowsExpand
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Prophylactic catheter ablation for the prevention of defibrillator therapy.
BACKGROUND For patients who have a ventricular tachyarrhythmic event, implantable cardioverter-defibrillators (ICDs) are a mainstay of therapy to prevent sudden death. However, ICD shocks areExpand
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Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective
OBJECTIVES The purpose of this study was to evaluate the feasibility and safety of periprocedural dabigatran during atrial fibrillation (AF) ablation. BACKGROUND AF ablation requires optimalExpand
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