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ganstigmine

Known as: (-)-O-((2'-ethylphenyl)carbamoyl)geneseroline hydrochloride, (4AS,9AS)-2,3,4,4a,9,9a-Hexahydro-2,4a,9-Trimethyl-1,2-Oxazino(6,5-B)Indol-6-Yl O-Ethylcarbanilate 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

AlkaloidsCarbamates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.
2007
2007
Neurochemical and neurobehavioral effects of ganstigmine (CHF2819), a novel acetylcholinesterase inhibitor, in rat prefrontal cortex: an in vivo study.
2003
2003
Characterization of the effect of ganstigmine (CHF2819) on amyloid precursor protein metabolism in SH-SY5Y neuroblastoma cells
Summary. We have investigated the effect of ganstigmine (CHF2819), a novel geneserine derived acetylcholinesterase (AChE… 
2003
2003
First Clinical Evaluation of Ganstigmine in Patients With Probable Alzheimer's Disease
The objective of this study was to evaluate the safety, tolerability, maximum tolerated dose, pharmacokinetics, and… 
2003
2003
Characterization of Ganstigmine metabolites in hepatocytes by low- and high-resolution mass spectrometry coupled with liquid chromatography.
In order to deepen the understanding of the metabolism of Ganstigmine, a new acetylcholinesterase inhibitor under evaluation for… 
Review
2003
Review
2003
Ganstigmine. Chiesi.
Ganstigmine (CHF-2819) is being developed by Chiesi as a potential treatment for neurodegenerative and cognitive disorders. The… 
Review
2002
Review
2002
Ganstigmine (CHF 2819).
2002
2002
Ganstigmine: pharmacological profile promising for Alzheimer's disease
  • 2002
  • Corpus ID: 195127223
2001
2001
Phase I metabolism of ganstigmine. Rat, dog, monkey and human liver microsomal extracts investigated by liquid chromatography electrospray tandem mass spectrometry.
Ganstigmine, a new acetylcholinesterase inhibitor, was incubated with rat liver microsomes and the resulting metabolites were… 
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