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gaboxadol

Known as: 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol, THIP 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

AnalgesicsAnticonvulsantsGABA AgonistsIsoxazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Inhibition of thalamic excitability by 4,5,6,7‐tetrahydroisoxazolo[4,5‐c]pyridine‐3‐ol: a selective role for δ‐GABAA receptors
The sedative and hypnotic agent 4,5,6,7‐tetrahydroisoxazolo[4,5‐c]pyridine‐3‐ol (THIP) is a GABAA receptor (GABAAR) agonist that… 
Highly Cited
2007
Highly Cited
2007
GABAergic modulation of binge-like ethanol intake in C57BL/6J mice
Highly Cited
1999
Highly Cited
1999
Differential effects of GABAA and GABAB agonists on sensitization to the locomotor stimulant effects of ethanol in DBA/2 J mice
Abstract Contemporary theories of drug abuse suggest that behavioral sensitization plays an important role in addiction. However… 
Highly Cited
1992
Highly Cited
1992
GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats.
Treatment with the GABAA agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) or the GABAB agonist baclofen was shown to… 
Highly Cited
1987
Highly Cited
1987
The THIP-induced model of bilateral synchronous spike and wave in rodents
Highly Cited
1985
Highly Cited
1985
Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray.
Highly Cited
1984
Highly Cited
1984
Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mallike epilepsy
Highly Cited
1984
Highly Cited
1984
Differential interactions of GABA agonists, depressant and convulsant drugs with [35S]-t-butylbicyclophosphorothionate binding sites in cortex and cerebellum
Highly Cited
1982
Highly Cited
1982
Comparative assay of anticonvulsant and toxic potencies of sixteen GABAmimetic drugs
Highly Cited
1979
Highly Cited
1979
Characterization of [3H]muscimol binding to mouse brain membranes.
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