GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats.

@article{Smith1992GABAergicII,
  title={GABAergic involvement in the acquisition of voluntary ethanol intake in laboratory rats.},
  author={Brian Robert Smith and J Robidoux and Zalman Amit},
  journal={Alcohol and alcoholism},
  year={1992},
  volume={27 3},
  pages={
          227-31
        }
}
Treatment with the GABAA agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol) or the GABAB agonist baclofen was shown to enhance the acquisition of voluntary ethanol consumption in laboratory rats. THIP administration resulted in an increased intake of absolute ethanol without an increase in total fluid intake. In contrast, baclofen administration, while increasing ethanol intake in a manner similar to that seen with THIP, also increased total fluid intake, indicating that its effects… CONTINUE READING

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