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furamidine
Known as:
2,5-BAPF
, 2,5-bis(4-amidinophenyl)furan
, 2,5-bis(4-guanylphenyl)furan
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (2)
Amidines
Benzamidines
Narrower (1)
DB75
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
X. Ming
,
Wujian Ju
,
Huali Wu
,
R. Tidwell
,
J. Hall
,
D. Thakker
Drug Metabolism And Disposition
2009
Corpus ID: 20588545
The antiparasitic activity of aromatic diamidine drugs, pentamidine and furamidine, depends on their entry into the pathogenic…
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Review
2008
Review
2008
Antiparasitic compounds that target DNA.
W. Wilson
,
F. Tanious
,
A. Mathis
,
D. Tevis
,
J. Hall
,
D. Boykin
Biochimie
2008
Corpus ID: 10159634
Highly Cited
2008
Highly Cited
2008
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis.
J. Thuita
,
S. Karanja
,
+5 authors
R. Brun
Acta Tropica
2008
Corpus ID: 35767762
Highly Cited
2008
Highly Cited
2008
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
M. Ismail
,
R. Arafa
,
+4 authors
D. Boykin
Bioorganic & Medicinal Chemistry
2008
Corpus ID: 33011961
Highly Cited
2007
Highly Cited
2007
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
Smitha Antony
,
C. Marchand
,
+4 authors
Y. Pommier
Nucleic Acids Research
2007
Corpus ID: 9018223
By enzymatically hydrolyzing the terminal phosphodiester bond at the 3′-ends of DNA breaks, tyrosyl-DNA phosphodiesterase (Tdp1…
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Highly Cited
2006
Highly Cited
2006
Roles for the Trypanosoma brucei P2 Transporter in DB75 Uptake and Resistance
C. Lanteri
,
M. Stewart
,
+4 authors
M. Barrett
Molecular Pharmacology
2006
Corpus ID: 410843
A novel trypanocide, 2,5-bis(4-amidinophenyl)furan (DB75), in its prodrug amidoxime-derivative form, 2,5-bis(4-amidinophenyl…
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Highly Cited
2004
Highly Cited
2004
Characterization of a novel DNA minor-groove complex.
Binh Nguyen
,
D. Hamelberg
,
+5 authors
W. Wilson
Biophysical Journal
2004
Corpus ID: 41651347
Highly Cited
2003
Highly Cited
2003
Synthesis and antiprotozoal activity of aza-analogues of furamidine.
M. Ismail
,
R. Brun
,
J. Easterbrook
,
F. Tanious
,
W. Wilson
,
D. Boykin
Journal of Medicinal Chemistry
2003
Corpus ID: 38545663
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine (8a) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile (4a…
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Highly Cited
1995
Highly Cited
1995
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
D. Boykin
,
A. Kumar
,
+7 authors
R. Tidwell
Journal of Medicinal Chemistry
1995
Corpus ID: 23123501
Seven dicationic 2,5-diarylfurans have been synthesized, and their interactions with poly(dA-dT) and the duplex oligomer d…
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Highly Cited
1977
Highly Cited
1977
Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans.
B. Das
,
D. Boykin
Journal of Medicinal Chemistry
1977
Corpus ID: 21639642
Eighteen substituted 2,5-bis(4-guanylphenyl)furans and related analogues, including "masked" amidines in which the guanyl…
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