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furamidine

Known as: 2,5-BAPF, 2,5-bis(4-amidinophenyl)furan, 2,5-bis(4-guanylphenyl)furan 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AmidinesBenzamidines

Narrower (1)

DB75

Papers overview

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2011
2011
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.
Current therapies for human African trypanosomiasis (HAT) are unsatisfactory and under threat from emerging drug resistance… Expand
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Highly Cited
2009
Highly Cited
2009
Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
The antiparasitic activity of aromatic diamidine drugs, pentamidine and furamidine, depends on their entry into the pathogenic… Expand
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Highly Cited
2009
Highly Cited
2009
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
African sleeping sickness is a fatal parasitic disease, and all drugs currently in use for treatment have strong liabilities. It… Expand
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Review
2008
Review
2008
Antiparasitic compounds that target DNA.
Designed, synthetic heterocyclic diamidines have excellent activity against eukaryotic parasites that cause diseases such as… Expand
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Highly Cited
2007
Highly Cited
2007
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
By enzymatically hydrolyzing the terminal phosphodiester bond at the 3′-ends of DNA breaks, tyrosyl-DNA phosphodiesterase (Tdp1… Expand
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2004
2004
Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis.
Furamidine (DB75) and related unfused aromatic diamidines have proven useful for the treatment of parasitic infections. These… Expand
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2004
2004
DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae.
The aromatic diamidines represent a class of compounds with broad-spectrum antimicrobial activity; however, their development is… Expand
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2003
2003
Synthesis and antiprotozoal activity of aza-analogues of furamidine.
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine (8a) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile (4a… Expand
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2002
2002
Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution.
Diphenylfuran diamidines represent an important class of DNA minor groove binders of high therapeutic interest as antiparasitic… Expand
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2002
2002
Distribution of furamidine analogues in tumor cells: influence of the number of positive charges.
Fluorescence microscopy has been used to study the cellular distribution properties of a series of DNA binding cationic compounds… Expand
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