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furamidine

Known as: 2,5-BAPF, 2,5-bis(4-amidinophenyl)furan, 2,5-bis(4-guanylphenyl)furan 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AmidinesBenzamidines

Narrower (1)

DB75

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Trypanocidal Furamidine Analogues: Influence of Pyridine Nitrogens on Trypanocidal Activity, Transport Kinetics, and Resistance Patterns
ABSTRACT Current therapies for human African trypanosomiasis (HAT) are unsatisfactory and under threat from emerging drug… Expand
Highly Cited
2009
Highly Cited
2009
Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
The antiparasitic activity of aromatic diamidine drugs, pentamidine and furamidine, depends on their entry into the pathogenic… Expand
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Review
2008
Review
2008
Antiparasitic compounds that target DNA.
Designed, synthetic heterocyclic diamidines have excellent activity against eukaryotic parasites that cause diseases such as… Expand
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Highly Cited
2007
Highly Cited
2007
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1
By enzymatically hydrolyzing the terminal phosphodiester bond at the 3′-ends of DNA breaks, tyrosyl-DNA phosphodiesterase (Tdp1… Expand
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Highly Cited
2006
Highly Cited
2006
Roles for the Trypanosoma brucei P2 Transporter in DB75 Uptake and Resistance
A novel trypanocide, 2,5-bis(4-amidinophenyl)furan (DB75), in its prodrug amidoxime-derivative form, 2,5-bis(4-amidinophenyl… Expand
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2004
2004
Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
The current epidemic of sleeping sickness, also known as human African trypanosomiasis in sub-Saharan Africa places nearly 60… Expand
2004
2004
Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.
DB75 (2,5-bis(4-amidinophenyl)furan) is a promising antimicrobial agent against African trypanosomiasis and Pneumocystis carinii… Expand
Highly Cited
2003
Highly Cited
2003
Synthesis and antiprotozoal activity of aza-analogues of furamidine.
6-[5-(4-Amidinophenyl)furan-2-yl]nicotinamidine (8a) was synthesized from 6-[5-(4-cyanophenyl)furan-2-yl]nicotinonitrile (4a… Expand
Highly Cited
1995
Highly Cited
1995
Dicationic diarylfurans as anti-Pneumocystis carinii agents.
Seven dicationic 2,5-diarylfurans have been synthesized, and their interactions with poly(dA-dT) and the duplex oligomer d… Expand
Highly Cited
1977
Highly Cited
1977
Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)furans.
Eighteen substituted 2,5-bis(4-guanylphenyl)furans and related analogues, including "masked" amidines in which the guanyl… Expand
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