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Benzamidines

Known as: Benzamidines [Chemical/Ingredient] 
Amidines substituted with a benzene group. Benzamidine and its derivatives are known as peptidase inhibitors.
National Institutes of Health

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2-aminobenzamidoxime3,4,5-trihydroxybenzamidoxime3,5-dipentadecyloxybenzamidine hydrochloride4'-amidinophenyl-4-chloroanthranilic acid
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

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2015
2015
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.
Highly Cited
2012
Highly Cited
2012
Copper-catalyzed synthesis of quinazolines in water starting from o-bromobenzylbromides and benzamidines.
Water makes it possible: The Cu(2)O-catalyzed reaction between easily available o-bromobenzylbromides and benzamidines by using… 
Highly Cited
2012
Highly Cited
2012
Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a Chan-Lam-Evans N-arylation and C-H activation/C-N bond forming process.
Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu… 
Highly Cited
2010
Highly Cited
2010
Direct synthesis of quinazolines through copper-catalyzed reaction of aniline-derived benzamidines.
A novel synthesis of 2-phenyl-4-[(triisopropylsilyl)methyl]quinazolines from monosubstituted arenes has been developed. Treatment… 
Highly Cited
2002
Highly Cited
2002
A new catalytic cross-coupling approach for the synthesis of protected aryl and heteroaryl amidines.
[reaction: see text] A new method for the synthesis of protected benzamidines is described. The commercially available 1,3-bis… 
Highly Cited
2001
Highly Cited
2001
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
Matriptase, a trypsin-like serine protease, which may be involved in tissue remodeling, cancer invasion, and metastasis. Potent… 
Highly Cited
2001
Highly Cited
2001
Thermodynamic analysis of binding of p-substituted benzamidines to trypsin.
Understanding the structural basis of inhibitor-enzyme interactions, important for the design of new drugs, requires a complete… 
1987
1987
Hepatic microsomal N-demethylation of N-methylbenzamidine. N-dealkylation vs N-oxygenation of amidines.
1983
1983
The N-oxidation of benzamidines in vitro.
  • B. Clement
  • Xenobiotica; the fate of foreign compounds in…
  • 1983
  • Corpus ID: 37454032
The enzymic N-oxidation of a series of N-unsubstituted basic benzamidines (I) to a new type of metabolite, the amidoximes (II… 
1978
1978
Inhibition of four human serine proteases by substituted benzamidines.
A series of substituted benzamidines has been examined for their inhibitory activity against the human serine proteases--trypsin… 
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