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3,4,5-trihydroxybenzamidoxime

Known as: trimidox 
National Institutes of Health

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4 relations

Broader (3)

BenzamidinesEnzyme InhibitorsFree Radical Scavengers

Narrower (1)

VF 233

Papers overview

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2005
2005
Combination of inhibitors of lymphocyte activation (hydroxyurea, trimidox, and didox) and reverse transcriptase (didanosine) suppresses development of murine retrovirus-induced lymphoproliferative…
Highly Cited
2004
Highly Cited
2004
Characterization of a Gemcitabine-Resistant Murine Leukemic Cell Line
Resistance to cytotoxic nucleoside analogues is a major problem in cancer treatment. The cellular mechanisms involved in this… 
2002
2002
Suppression of retrovirus-induced immunodeficiency disease (murine AIDS) by trimidox and didox: novel ribonucleotide reductase inhibitors with less bone marrow toxicity than hydroxyurea.
2000
2000
Enhancement of hemoglobin and F‐cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with…
Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F‐cells. Fetal… 
2000
2000
The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells.
1999
1999
In Vivo and In Vitro Comparison of the Short‐Term Hematopoietic Toxicity Between Hydroxyurea and Trimidox or Didox, Novel Ribonucleotide Reductase Inhibitors with Potential Anti‐HIV‐1 Activity
Inhibitors of the cellular enzyme ribonucleotide reductase (hydroxyurea, [HU]) have been proposed as a new therapeutic strategy… 
1998
1998
Enhanced effects of adriamycin by combination with a new ribonucleotide reductase inhibitor, trimidox, in murine leukemia.
1997
1997
DNA-protective activity of new ribonucleotide reductase inhibitors.
The DNA-protective activity of hydroxyurea (HU) and novel ribonucleotide reductase (RR) inhibitors amidox (AX), didox (DX) and… 
1997
1997
Selective inhibition of l kappaB alpha phosphorylation and HIV-1 LTR-directed gene expression by novel antioxidant compounds.
Oxidative stress activates the NF-kappaB/Rel transcription factors which are involved in the activation of numerous… 
1994
1994
Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells.
Increased ribonucleotide reductase (RR) activity has been linked with malignant transformation and tumor cell growth. Therefore… 
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