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3,4,5-trihydroxybenzamidoxime
Known as:
trimidox
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (3)
Benzamidines
Enzyme Inhibitors
Free Radical Scavengers
Narrower (1)
VF 233
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells.
S. Madlener
,
C. Illmer
,
+9 authors
T. Szekeres
Cancer Letters
2007
Corpus ID: 35029901
Highly Cited
2004
Highly Cited
2004
Characterization of a Gemcitabine-Resistant Murine Leukemic Cell Line
L. Jordheim
,
E. Cros
,
+5 authors
C. Dumontet
Clinical Cancer Research
2004
Corpus ID: 17174389
Resistance to cytotoxic nucleoside analogues is a major problem in cancer treatment. The cellular mechanisms involved in this…
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Highly Cited
2003
Highly Cited
2003
Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants
J. Turchan
,
C. Pocernich
,
+10 authors
A. Nath
Neurology
2003
Corpus ID: 7527900
Objective: To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that…
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2002
2002
Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells.
M. Fritzer‐Szekeres
,
A. Salamon
,
+7 authors
T. Szekeres
Biochemical Pharmacology
2002
Corpus ID: 46023786
2000
2000
Enhancement of hemoglobin and F‐cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with…
W. E. Iyamu
,
S. Adunyah
,
+4 authors
E. Turner
American journal of hematology/oncology
2000
Corpus ID: 25251380
Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F‐cells. Fetal…
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2000
2000
The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells.
G. Rosenberger
,
G. Fuhrmann
,
+6 authors
G. Krupitza
Life Science
2000
Corpus ID: 25559520
1999
1999
In Vivo and In Vitro Comparison of the Short‐Term Hematopoietic Toxicity Between Hydroxyurea and Trimidox or Didox, Novel Ribonucleotide Reductase Inhibitors with Potential Anti‐HIV‐1 Activity
C. Mayhew
,
J. Phillips
,
R. Greenberg
,
N. J. Birch
,
H. Elford
,
V. Gallicchio
Stem Cells
1999
Corpus ID: 21198316
Inhibitors of the cellular enzyme ribonucleotide reductase (hydroxyurea, [HU]) have been proposed as a new therapeutic strategy…
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1997
1997
DNA-protective activity of new ribonucleotide reductase inhibitors.
P. Rauko
,
D. Romanova
,
+4 authors
T. Szekeres
Anticancer Research
1997
Corpus ID: 41664727
The DNA-protective activity of hydroxyurea (HU) and novel ribonucleotide reductase (RR) inhibitors amidox (AX), didox (DX) and…
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1995
1995
Iron Binding Capacity of Trimidox (3,4,5-Trihydroxybenzamidoxime), a New Inhibitor of the Enzyme Ribonucleotide Reductase
T. Szekeres
,
E. Vielnascher
,
+6 authors
H. Goldenberg
European journal of clinical chemistry and…
1995
Corpus ID: 30251953
Ribonucleotide reductase is the rate limiting enzyme of deoxynucleoside triphosphate synthesis and is considered to be an…
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1994
1994
Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells.
T. Szekeres
,
M. Fritzer
,
+6 authors
H. Jayaram
Blood
1994
Corpus ID: 929098
Increased ribonucleotide reductase (RR) activity has been linked with malignant transformation and tumor cell growth. Therefore…
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