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3,4,5-trihydroxybenzamidoxime

Known as: trimidox 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

BenzamidinesEnzyme InhibitorsFree Radical Scavengers

Narrower (1)

VF 233

Papers overview

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2013
2013
Ribonucleotide reductase inhibitors hydroxyurea, didox, and trimidox inhibit human cytomegalovirus replication in vitro and synergize with ganciclovir.
Ganciclovir (GCV) is a deoxyguanosine analog that is effective in inhibiting human cytomegalovirus (HCMV) replication. In… Expand
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Highly Cited
2007
Highly Cited
2007
Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells.
Gallic acid (GA) is a naturally occurring polyhydroxyphenolic compound and an excellent free radical scavenger. In this study, we… Expand
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Highly Cited
2004
Highly Cited
2004
Characterization of a Gemcitabine-Resistant Murine Leukemic Cell Line
Resistance to cytotoxic nucleoside analogues is a major problem in cancer treatment. The cellular mechanisms involved in this… Expand
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Highly Cited
2003
Highly Cited
2003
Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants
Objective: To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that… Expand
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2003
2003
Combined effects of temozolomide and the ribonucleotide reductase inhibitors didox and trimidox in malignant brain tumor cells
PurposeTemozolomide (TMZ), an oral alkylating agent with good penetration of the blood-brain barrier, has shown efficacy in the… Expand
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2000
2000
Enhancement of hemoglobin and F‐cell production by targeting growth inhibition and differentiation of K562 cells with ribonucleotide reductase inhibitors (didox and trimidox) in combination with…
Upon appropriate drug treatment, the human erythroleukemic K562 cells have been shown to produce hemoglobin and F‐cells. Fetal… Expand
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2000
2000
The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells.
Trimidox (3,4,5-trihydroxybenzohydroxamidoxime), a recently synthesized inhibitor of ribonucleotide reductase (RR), was shown to… Expand
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1999
1999
In vivo and in vitro comparison of the short-term hematopoietic toxicity between hydroxyurea and trimidox or didox, novel ribonucleotide reductase inhibitors with potential anti-HIV-1 activity.
Inhibitors of the cellular enzyme ribonucleotide reductase (hydroxyurea, [HU]) have been proposed as a new therapeutic strategy… Expand
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1997
1997
DNA-protective activity of new ribonucleotide reductase inhibitors.
The DNA-protective activity of hydroxyurea (HU) and novel ribonucleotide reductase (RR) inhibitors amidox (AX), didox (DX) and… Expand
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1995
1995
Iron Binding Capacity of Trimidox (3,4,5-Trihydroxybenzamidoxime), a New Inhibitor of the Enzyme Ribonucleotide Reductase
Ribonucleotide reductase is the rate limiting enzyme of deoxynucleoside triphosphate synthesis and is considered to be an… Expand
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