fumarate

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1935-2018
05010015019352017

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Highly Cited
2012
Highly Cited
2012
Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are mutated in a subset of human cancers… (More)
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Highly Cited
2011
Highly Cited
2011
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that catalyses the hydration of fumarate into… (More)
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Highly Cited
2011
Highly Cited
2011
The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose inactivation is associated with the development… (More)
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Highly Cited
2005
Highly Cited
2005
Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors… (More)
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Highly Cited
2005
Highly Cited
2005
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) and fumarate hydratase, both… (More)
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Highly Cited
2005
Highly Cited
2005
The nuclear-encoded Krebs cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour… (More)
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Highly Cited
2003
Highly Cited
2003
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant disorder characterized by smooth-muscle tumors… (More)
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Highly Cited
2002
Highly Cited
2002
Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is known about their etiology and… (More)
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Highly Cited
1999
Highly Cited
1999
The integral membrane protein fumarate reductase catalyzes the final step of anaerobic respiration when fumarate is the terminal… (More)
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Highly Cited
1993
Highly Cited
1993
Oxidation of succinate to fumarate is an energetically difficult step in the biochemical pathway of propionate oxidation by… (More)
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