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Electrospinning of polymeric nanofibers for tissue engineering applications: a review.
Electrospinning is examined by providing a brief description of the theory behind the process, examining the effect of changing the process parameters on fiber morphology, and discussing the potential applications and impacts of electrospinning on the field of tissue engineering.
Poly(ethylenimine) and its role in gene delivery.
Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner
It is indicated that fluid flow has far-reaching effects on osteoblast differentiation and phenotypic expression in vitro and can therefore be a valuable tool for both bone biology and tissue engineering.
Biomimetic materials for tissue engineering.
Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery.
It is found that complexes attach to cell surfaces and migrate into clumps that are endocytosed PEI, whether administered with or without DNA, undergoes nuclear localization in the form of ordered structures.
Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle.
It is found that, for the polymers tested, transfection efficiency increased as the molecular weight of PEI increased, and the pH of the PEI solutions prior to DNA complexation has no such effect.
Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor.
The better mixing provided in the spinner flask, external to the outer surface of the scaffolds, may explain the accelerated proliferation and differentiation of marrow stromal osteoblasts, and the localization of the enhanced mineralization on the external surface ofThe scaffolds.
Electrospun poly(epsilon-caprolactone) microfiber and multilayer nanofiber/microfiber scaffolds: characterization of scaffolds and measurement of cellular infiltration.
The scaffold design presented in this study allows for cellular infiltration into the scaffolds while at the same time providing nanofibers as a physical mimicry of extracellular matrix.