• Publications
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EcoCyc: fusing model organism databases with systems biology
EcoCyc is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655, and the development of EcoCyc as a teaching tool is increasing the impact of the knowledge collected in Eco cycl. Expand
EcoCyc: a comprehensive database of Escherichia coli biology
EcoCyc (http://Eco Cyc.org) is a comprehensive model organism database for Escherichia coli K-12 MG1655 displaying a graphical overview of all known regulatory inputs to gene expression and protein activity. Expand
EcoCyc: A comprehensive view of Escherichia coli biology
Software and Web site enhancements include the addition of tracks to the EcoCyc genome browser, in particular a type of track designed for the display of ChIP-chip datasets, and the development of a comparative genome browser. Expand
Structure of the Escherichia coli response regulator NarL.
Docking of a B-DNA duplex against the isolated C-terminal domain in the manner observed in paired protein and other H-T-H proteins suggests a stereochemical basis for DNA sequence preference: T-R-C-Y-Y (high affinity) or T- R-C -T-N (low affinity), which is close to the experimentally observed consensus sequence. Expand
Genomic insights into syntrophy: the paradigm for anaerobic metabolic cooperation.
Syntrophy is a tightly coupled mutualistic interaction between hydrogen-/formate-producing and hydrogen-/formate-using microorganisms that occurs throughout the microbial world. Syntrophy isExpand
The genome of Methanosarcina mazei: evidence for lateral gene transfer between bacteria and archaea.
Findings might indicate that lateral gene transfer has played an important evolutionary role in forging the physiology of this metabolically versatile methanogen. Expand
Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with pathogenic congeners.
The genome sequence of V. fischeri ES114 is reported, which enters into a mutualistic symbiosis in the light organ of the bobtail squid, Euprymna scolopes, and analysis of this sequence has revealed surprising parallels with V. cholerae and other pathogens. Expand
Syntrophy in anaerobic global carbon cycles.
Genomic analyses reveal that multiple mechanisms exist for reverse electron transfer and Surprisingly, the flagellum functions were implicated in ensuring close physical proximity and synchronization of the syntrophic partners. Expand
Global Gene Expression Profiling in Escherichia coli K12
DNA microarray technology is employed to identify genes involved in the regulatory networks that facilitate the transition of Escherichia coli cells from an aerobic to an anaerobic growth state and an approach is described for identifying gene expression patterns (clusters) obtained from multiple perturbation experiments based on a subset of genes that exhibit high probability for differential expression values. Expand
The nrfA and nirB Nitrite Reductase Operons in Escherichia coli Are Expressed Differently in Response to Nitrate than to Nitrite
  • Henian Wang, R. Gunsalus
  • Medicine, Biology
  • Journal of bacteriology
  • 15 October 2000
Steady-state gene expression studies revealed a differential pattern of nitrite reductase gene expression where optimal nrfA-lacZ expression occurred only at low to intermediate levels of nitrate and where nirB-l BacZ expression was induced only by high nitrate conditions. Expand