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fructose 2,6-diphosphate

Known as: phosphofructokinase activator, fructose 2,6-biphosphate, fructose 2,6-bisphosphate 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer
In human cancers, loss of PTEN, stabilization of hypoxia inducible factor-1α, and activation of Ras and AKT converge to increase… 
Highly Cited
2009
Highly Cited
2009
Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases*
The regulation of metabolism and growth must be tightly coupled to guarantee the efficient use of energy and anabolic substrates… 
Highly Cited
2005
Highly Cited
2005
Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer
Purpose: Fructose 2,6-bisphosphate (F2,6BP) is a potent activator of phosphofructokinase, which is a rate-limiting enzyme of… 
Highly Cited
2000
Highly Cited
2000
The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle.
Severe infection or tissue invasion can provoke a catabolic response, leading to severe metabolic derangement, cachexia, and even… 
Highly Cited
1992
Highly Cited
1992
Effects of overexpression of phosphofructokinase on glycolysis in the yeast Saccharomyces cerevisiae.
The influence of 6-phosphofructo-1-kinase on glycolytic flux in the yeast Saccharomyces cerevisiae was assessed by measuring the… 
Highly Cited
1989
Highly Cited
1989
Banana ripening: implications of changes in glycolytic intermediate concentrations, glycolytic and gluconeogenic carbon flux, and fructose 2,6-bisphosphate concentration.
In ripening banana (Musa sp. [AAA group, Cavendish subgroup] cv Valery) fruit, the concentration of glycolytic intermediates… 
Review
1987
Review
1987
Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues.
Glycolysis is an ubiquitous metabolic pathway. In addition to its catabolic role, glycolysis also serves an anabolic function by… 
Highly Cited
1987
Highly Cited
1987
Inositol 1,4,5-trisphosphate releases Ca2+ from vacuolar membrane vesicles of oat roots.
Highly Cited
1983
Highly Cited
1983
A role for fructose 2,6-bisphosphate in the regulation of sucrose synthesis in spinach leaves.
The subcellular distribution of fructose 2,6-bisphosphate in spinach (Spinacia oleracea) leaves was studied using nonaqueous… 
Highly Cited
1981
Highly Cited
1981
Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors.
Rat liver 6-phosphofructokinase (ATP-D-fructose-6-phosphate 1-phosphotransferase, EC 2.7.1.11) was partially purified free of… 
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