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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
- S. Elbashir, J. Harborth, W. Lendeckel, A. Yalçin, K. Weber, T. Tuschl
- Biology, MedicineNature
- 24 May 2001
21-nucleotide siRNA duplexes provide a new tool for studying gene function in mammalian cells and may eventually be used as gene-specific therapeutics.
Identification of Tissue-Specific MicroRNAs from Mouse
- Mariana Lagos-Quintana, R. Rauhut, A. Yalçin, Jutta Meyer, W. Lendeckel, T. Tuschl
- Medicine, BiologyCurrent Biology
- 30 April 2002
34 novel miRNAs were identified by tissue-specific cloning of approximately 21-nucleotide RNAs from mouse and a miRNA was identified that appears to be the fruitfly and mammalian ortholog of C. elegans lin-4 stRNA.
The small RNA profile during Drosophila melanogaster development.
- A. Aravin, Mariana Lagos-Quintana, +6 authors T. Tuschl
- Biology, MedicineDevelopmental cell
- 1 August 2003
The small RNA profile of Drosophila melanogaster is described as a function of development and 178 repeat-associated small interfering RNAs (rasiRNAs) are isolated, suggesting that small RNAs participate in defining chromatin structure.
The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis
The results suggest that DGCR8 and Drosha interact in human cells and reside in a functional pri-miRNA processing complex.
Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth
- B. Clem, S. Telang, +10 authors J. Chesney
- Biology, MedicineMolecular Cancer Therapeutics
- 1 January 2008
3PO markedly attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines and is selectively cytostatic to ras-transformed human bronchial epithelial cells relative to normal human bronachial epithel cells.
Antisense-Mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development
It is demonstrated that injection of 2'O-methyl antisense oligoribonucleotides into early Drosophila embryos leads to specific and efficient depletion of microRNAs and thus permits systematic loss-of-function analysis in vivo.
Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases*
- A. Yalçin, B. Clem, +8 authors J. Chesney
- Biology, MedicineThe Journal of Biological Chemistry
- 27 May 2009
An unexpected role for PFKFB3 in nuclear signaling is demonstrated and it is indicated that Fru-2,6-BP may couple the activation of glucose metabolism with cell proliferation.
Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.
- A. Yalçin, S. Telang, B. Clem, J. Chesney
- Biology, MedicineExperimental and molecular pathology
- 1 June 2009
These studies suggest that selective depletion of intracellular F2,6BP in cancer cells may suppress glycolytic flux and decrease their survival, growth and invasiveness.
S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction
It is shown that, in the setting of obesity, inflammatory input through increased inducible nitric oxide synthase (iNOS) activity causes S-nitrosylation of a key UPR regulator, IRE1α, which leads to a progressive decline in hepatic I RE1α-mediated XBP1 splicing activity in both genetic and dietary models of obesity.
Ras transformation requires metabolic control by 6-phosphofructo-2-kinase
Data indicate that the PFKFB3 protein product may serve as an essential downstream metabolic mediator of oncogenic ras, and it is proposed that pharmacologic inhibition of this enzyme should selectively suppress the high rate of glycolysis and growth by cancer cells.