fotemustine

Known as: 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester, diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate, diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate 
A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Ipilimumab improves survival of patients with metastatic melanoma, many of whom develop brain metastases. Chemotherapy… (More)
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2009
2009
Standardized salvage treatment has not yet proved effective in glioblastoma multiforme (GBM) patients who receive prior standard… (More)
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2008
2008
To evaluate efficacy and safety of fotemustine chemotherapy in temozolomide (TMZ) pretreated adults with recurrent glioblastoma… (More)
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2008
2008
The present study aims to assess the feasibility and the effectiveness of a second-line Fotemustine chemotherapy in patients with… (More)
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Review
2006
Review
2006
Fotemustine is a cytotoxic alkylating agent, belonging to the group of nitrosourea family. Its mechanism of action is similar to… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE To compare fotemustine and dacarbazine (DTIC) in terms of overall response rate (ORR) as primary end-point and overall… (More)
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Highly Cited
2003
Highly Cited
2003
The main objective of this prospective multicentre randomized phase III study was to compare a combined regimen of fotemustine… (More)
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2001
2001
Acquired resistance to antineoplastic agents is a frequent obstacle in tumor therapy. Malignant melanoma cells are particularly… (More)
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1991
1991
38 adults with recurrent supratentorial malignant gliomas, including glioblastoma multiforme (21), anaplastic astrocytomas (9… (More)
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1990
1990
A total of 42 patients with cerebral metastases of malignant melanoma were included in this study of the nitrosourea fotemustine… (More)
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