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fotemustine

Known as: 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester, diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate, diethyl-1-(3-(2-chloroethyl)-3-nitrosoureido)ethylphosphonate 
A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND In the NIBIT-M1 study, we reported a promising activity of ipilimumab combined with fotemustine in metastatic melanoma… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND In uveal melanoma (UM) with metastatic disease limited to the liver, the effect of an intrahepatic treatment on… Expand
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Highly Cited
2013
Highly Cited
2013
The optimal combination of bevacizumab with cytotoxic or cytostatic drugs in recurrent glioblastoma is unknown. We performed a… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Ipilimumab improves survival of patients with metastatic melanoma, many of whom develop brain metastases. Chemotherapy… Expand
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Highly Cited
2009
Highly Cited
2009
Malignant melanomas are highly resistant to chemotherapy. First-line chemotherapeutics used in melanoma therapy are the… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE To compare fotemustine and dacarbazine (DTIC) in terms of overall response rate (ORR) as primary end-point and overall… Expand
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Highly Cited
2004
Highly Cited
2004
SummaryA total of 42 patients with cerebral metastases of malignant melanoma were included in this study of the nitrosourea… Expand
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Highly Cited
2002
Highly Cited
2002
Malignant melanoma of the uvea is remarkable for purely haematogenous dissemination and its tendency to metastasise to the liver… Expand
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Highly Cited
2001
Highly Cited
2001
Acquired resistance to antineoplastic agents is a frequent obstacle in tumor therapy. Malignant melanoma cells are particularly… Expand
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Highly Cited
1990
Highly Cited
1990
One hundred sixty‐nine patients with histologic evidence of disseminated malignant melanoma, including patients with cerebral… Expand
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