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fostamatinib

Known as: (6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-yl)Amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4H-Pyrido(3,2-B)(1,4)Oxazin-4-Yl)Methyl Dihydrogen Phosphate, 2H-Pyrido(3,2-B)-1,4-Oxazin-3(4H)-One, 6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)-4-Pyrimidinyl)Amino)-2,2-Dimethyl-4-((Phosphonooxy)Methyl)- 
A small molecule Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG… 
National Institutes of Health

Related topics

Related topics

4 relations
Fostamatinib DisodiumReceptor Tyrosine Kinase Inhibition

Broader (2)

OxazinesPyridines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Safety Profile of Fostamatinib, an Oral Spleen Tyrosine Kinase Inhibitor: A Meta-Analysis of Randomized Controlled Trials
Introduction: Fostamatinib, a spleen tyrosine kinase (Syk) inhibitor has been studied in clinical trials of chronic immunologic… 
2019
2019
Managing Chronic Immune Thrombocytopenia with Fostamatinib
Persistence of severe thrombocytopenia for more than a year — despite treatment with corticosteroids, rituximab, thrombopoietin… 
Review
2017
Review
2017
How I Treat How I treat autoimmune hemolytic anemia
The diagnosis, prognosis, and management of autoimmune hemolytic anemia (AIHA) continue to be challenging in current practice… 
2016
2016
Pharmaceutical Approval Update.
Coagulation factor IX (recombinant), albumin fusion protein (Idelvion) for hemophilia B; captisol-enabled melphalan hydrochloride… 
2015
2015
Characterization of the disposition of fostamatinib in Japanese subjects including pharmacokinetic assessment in dry blood spots: results from two phase I clinical studies
The aims of the present study were to characterize the pharmacokinetics of fostamatinib in two phase I studies in healthy… 
2014
2014
Modern treatment of rheumatoid arthritis in cows.
  • K. Ma
  • 2014
  • Corpus ID: 2667808
Rheumatoid arthritis (RA) is a chronic autoimmune disease, which is thought to be one of the major public health problems in the… 
2014
2014
The Effects of the Spleen Tyrosine Kinase Inhibitor, Fostamatinib, on an Immune Thrombocytopenia Mouse Model
Background: Immune thrombocytopenia (ITP) is the most common autoimmune bleeding disorder. The major mechanism involves the… 
2013
2013
AstraZeneca meddelar idag övergripande resultat i OSKIRA-1 - en fas 3 studie med fostamatinib för behandling av reumatoid artrit
AstraZeneca meddelar idag overgripande resultat i OSKIRA-1, en fas 3- studie for att bedoma effekt och sakerhet av fostamatinib… 
2013
2013
Inhibice signalizace B buněčným receptorem: první cílená léčba u chronické lymfocytární leukemie a dalších B buněčných lymfomů Inhibition of B Cell Receptor Signaling: A First Targeted Th erapeutic…
Chronicka lymfocytarni leukemie (CLL) je nejcastějsi a stale konvencnimi metodami nevylecitelnou leukemii dospěle populace v… 
2011
2011
Longer-term safety of fostamatinib (R788) in patients with rheumatoid arthritis. Analysis of clinical trial data from up to 2 years of exposure
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