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flavokawain B

Known as: flavokavain B 
National Institutes of Health

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Flavonoids
flavokavin B

Papers overview

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2020
2020
Antitumor effects of flavokawain-B flavonoid in gemcitabine-resistant lung cancer cells are mediated via mitochondrial-mediated apoptosis, ROS production, cell migration and cell invasion inhibition…
PURPOSE Drug resistance in lung cancer is a growing and challenging problem affecting the overall treatment and quality of the… 
2018
2018
UPLC-MS/MS determination of flavokawain B, a novel anti-tumor chemotherapeutic agent in rat plasma and its application to a pharmacokinetic study in rats.
A sensitive, selective and rapid ultra-performance liquid chromatography/tandem mass spectrometry method was developed and… 
2017
2017
An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53
R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273… 
2016
2016
Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro
BackgroundThe kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be… 
2016
2016
Gene Expression Analysis Reveals the Concurrent Activation of Proapoptotic and Antioxidant-Defensive Mechanisms in Flavokawain B–Treated Cervical Cancer HeLa Cells
Flavokawain B (FKB) is known to possess promising anticancer abilities. This is demonstrated in various cancer cell lines… 
2013
2013
Synthesis of Flavokawain B and Its anti‐Proliferative Activity Against Gefitinib‐Resistant Non‐Small Cell Lung Cancer (NSCLC).
The natural product flavokawain B (I) impairs the growth of gefitinib-resistant non-small cell lung cancer (H1975) and disrupted… 
2012
2012
Abstract 619: Flavokawain A inhibits urinary bladder carcinogenesis in the UPII-SV40T transgenic mouse bladder cancer model.
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL The UPII-SV40T transgenic model of the mouse… 
2011
2011
Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 expression.
Novel effective drugs are still urgently needed in the prevention and treatment of oral adenoid cystic carcinoma (ACC). In this… 
2011
2011
Abstract 4629: Ultra performance liquid chromatography (UPLC)-tandem mass spectrometry (MS/MS) method for analysis and pharmacokinetic study of flavokawain A, a novel chalcone from the kava plant, in…
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Kava consumption in three Pacific Island Nations (i.e… 
2011
2011
Abstract 4241: Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines
Synovial sarcoma (SS) is a soft tissue sarcoma with poor prognosis and lack of response to conventional cytotoxic chemotherapy… 
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