Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro.

@article{Abu2016FlavokawainBI,
  title={Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases In vitro.},
  author={N Abu and Muhammad Nadeem Akhtar and Swee Keong Yeap and Kian Lam Lim and Wan Yong Ho and Mohd. Puad Abdullah and Chai Ling Ho and Abdul Rahman Bin Omar and Jamil bin Ismail and Noorjahan Banu Mohamed Alitheen},
  journal={BMC complementary and alternative medicine},
  year={2016},
  volume={16},
  pages={86}
}
BACKGROUND The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated. METHOD Several in vitro assays were attempted such as MTT… CONTINUE READING
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The In Vitro and In Vivo Antiangiogenic Effects of Flavokawain B.

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