Skip to search formSkip to main contentSkip to account menu

fenclozic acid

Known as: 2-(4-chlorophenyl)-4--thiazoleacetic acid 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

ICI 54450

Broader (1)

Thiazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The metabolic fate of fenclozic acid in chimeric mice with a humanized liver
The metabolic fate of the human hepatotoxin fenclozic acid ([2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid) (Myalex) was… 
2016
2016
Acute liver effects, disposition and metabolic fate of [14C]-fenclozic acid following oral administration to normal and bile-cannulated male C57BL/6J mice
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following… 
2014
2014
The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse
Abstract 1. The distribution, metabolism, excretion and hepatic effects of fenclozic acid were investigated following a single… 
2014
2014
Identification of the reactive metabolites of fenclozic acid in bile duct cannulated rats.
Fenclozic acid (Myalex) was developed by ICI pharmaceuticals in the 1960s for the treatment of rheumatoid arthritis and was a… 
1983
1983
The fate of fenclozic acid in the gut and its effect on some aspects of gut metabolism.
In the rat [14C]fenclozic acid is not metabolized in the gut and passes into the portal blood unchanged. After intraduodenal… 
1981
1981
The enhanced biliary secretion of a taurine conjugate in the rat after intraduodenal administration of high doses of fenclozic acid.
1. The metabolic fate of [14C]fenclozic acid (ICI 54450) in rat was determined after intraduodenal administration at different… 
1971
1971
Pharmacokinetics of fenclozic acid in animals and man.
The pharmacokinetic properties of the anti-inflammatory agent, fenclozic acid, have been established in the dog, calf, sheep, and… 
1969
1969
The pharmacology of fenclozic acid (2‐(4‐chlorophenyl)‐thiazol‐4‐ylacetic acid; I.C.I. 54, 450; ‘Myalex’); a new compound with anti‐inflammatory, analgesic and antipyretic activity
1 Fenclozic acid (2‐(4‐chlorophenyl)thiazol‐4‐ylacetic acid; I.C.I. 54, 450; “Myalex”) is one representative of a new class of… 
1969
1969
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflamatory agent. II. Clinical trial in patients with rheumatoid arthritis.
Inthepharmacological evaluation ofanewdrug muchistobegained byclose co-operation between clinical andindustrial research… 
1969
1969
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis.
Fenclozic acid (I.C.I. 54,450; 2-(p-chlorophenyl) thiazol-4-ylacetic acid; Myalex*) (Hepworth, Newbould, Platt, and Stacey, 1969… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)