fenclozic acid

Known as: 2-(4-chlorophenyl)-4--thiazoleacetic acid 
 

Topic mentions per year

Topic mentions per year

1969-2015
012319692015

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2015
2015
Xenobiotic carboxylic acids may be metabolized to oxidative metabolites, acyl glucuronides, and/or S-acyl-CoA thioesters (CoA… (More)
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2014
2014
1. The distribution, metabolism, excretion and hepatic effects of fenclozic acid were investigated following a single oral dose… (More)
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2014
2014
Fenclozic acid (Myalex) was developed by ICI pharmaceuticals in the 1960s for the treatment of rheumatoid arthritis and was a… (More)
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2013
2013
The carboxylic acid NSAID fenclozic acid exhibited an excellent preclinical safety profile and promising clinical efficacy, yet… (More)
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1982
1982
It is shown that the absorption of phenylbutazone, naproxen, and chlorthiazide is governed by a dose limiting mechanism. This… (More)
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1981
1981
1. The metabolic fate of [14C]fenclozic acid (ICI 54450) in rat was determined after intraduodenal administration at different… (More)
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1979
1979
Fenclozic acid, a prostaglandin synthesis inhibitor, was administered to male rats by stomach intubation. A second group of rats… (More)
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1970
1970
Fenclozic acid (I.C.I. 54,450: Myalex) has recently been withdrawn from trial because of hepatotoxicity. In a published trial… (More)
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1969
1969
1. Fenclozic acid (2-(4-chlorophenyl)thiazol-4-ylacetic acid; I.C.I. 54,450; "Myalex") is one representative of a new class of… (More)
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1969
1969
Fenclozic acid (I.C.I. 54,450; 2-(p-chlorophenyl) thiazol-4-ylacetic acid; Myalex*) (Hepworth, Newbould, Platt, and Stacey, 1969… (More)
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