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fenclozic acid

Known as: 2-(4-chlorophenyl)-4--thiazoleacetic acid 
National Institutes of Health

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Related topics

2 relations

Narrower (1)

ICI 54450

Broader (1)

Thiazoles

Papers overview

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2017
2017
Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid.
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit no functional expression of hepatic cytochrome P450 (P450… 
2014
2014
The metabolic fate of [14C]-fenclozic acid in the hepatic reductase null (HRN) mouse
Abstract 1. The distribution, metabolism, excretion and hepatic effects of fenclozic acid were investigated following a single… 
2014
2014
Identification of the reactive metabolites of fenclozic acid in bile duct cannulated rats.
Fenclozic acid (Myalex) was developed by ICI pharmaceuticals in the 1960s for the treatment of rheumatoid arthritis and was a… 
1983
1983
The fate of fenclozic acid in the gut and its effect on some aspects of gut metabolism.
In the rat [14C]fenclozic acid is not metabolized in the gut and passes into the portal blood unchanged. After intraduodenal… 
1981
1981
The enhanced biliary secretion of a taurine conjugate in the rat after intraduodenal administration of high doses of fenclozic acid.
1. The metabolic fate of [14C]fenclozic acid (ICI 54450) in rat was determined after intraduodenal administration at different… 
1979
1979
The effects of fenclozic acid on fertility of male rats.
1971
1971
Pharmacokinetics of fenclozic acid in animals and man.
The pharmacokinetic properties of the anti-inflammatory agent, fenclozic acid, have been established in the dog, calf, sheep, and… 
1969
1969
The pharmacology of fenclozic acid (2‐(4‐chlorophenyl)‐thiazol‐4‐ylacetic acid; I.C.I. 54, 450; ‘Myalex’); a new compound with anti‐inflammatory, analgesic and antipyretic activity
1 Fenclozic acid (2‐(4‐chlorophenyl)thiazol‐4‐ylacetic acid; I.C.I. 54, 450; “Myalex”) is one representative of a new class of… 
1969
1969
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflamatory agent. II. Clinical trial in patients with rheumatoid arthritis.
Inthepharmacological evaluation ofanewdrug muchistobegained byclose co-operation between clinical andindustrial research… 
1969
1969
Evaluation in man of fenclozic acid (I.C.I. 54,450: Myalex), a new anti-inflammatory agent. I. Serum concentration studies in healthy individuals and in patients with rheumatoid arthritis.
Fenclozic acid (I.C.I. 54,450; 2-(p-chlorophenyl) thiazol-4-ylacetic acid; Myalex*) (Hepworth, Newbould, Platt, and Stacey, 1969… 
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