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fatty-acid synthase activity

Known as: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing), lovastatin nonaketide synthase activity, acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) 
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9… Expand
National Institutes of Health

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Fatty-acid synthase

Papers overview

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Highly Cited
2010
Highly Cited
2010
Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.
Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the… Expand
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Highly Cited
2005
Highly Cited
2005
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
The consumption of food products containing high amounts of flavonoids has been reported to lower the risk of various cancers… Expand
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Highly Cited
2005
Highly Cited
2005
Insulin acutely decreases hepatic fatty acid synthase activity.
Insulin is viewed as a positive regulator of fatty acid synthesis by increasing fatty acid synthase (FAS) mRNA transcription. We… Expand
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Highly Cited
2002
Highly Cited
2002
Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.
The effects of low extracellular pH and intracellular accumulation of weak organic acids were compared with respect to fatty acid… Expand
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Highly Cited
2001
Highly Cited
2001
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
Fatty acid synthetic metabolism is abnormally elevated in tumor cells, and pharmacological inhibitors of the anabolic enzyme… Expand
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Highly Cited
2001
Highly Cited
2001
Angiotensinogen-Deficient Mice Exhibit Impairment of Diet-Induced Weight Gain with Alteration in Adipose Tissue Development and Increased Locomotor Activity.
White adipose tissue is known to contain the components of the renin-angiotensin system, which gives rise to angiotensin II from… Expand
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1998
1998
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
The aim of this study was to evaluate the chronic effects of a short-chain fructo-oligosaccharide (FOS)-containing diet on plasma… Expand
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Highly Cited
1993
Highly Cited
1993
Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation.
1. Viable myocytes were obtained from rat hearts. Oxidation of [1-14C]palmitate by these cells could be decreased by the addition… Expand
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1993
1993
Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability.
Carbohydrate feeding of animals results in striking increases in hepatic fatty acid synthesis but much of this induction is… Expand
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Highly Cited
1986
Highly Cited
1986
Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase.
Fatty-acid synthase has been purified to homogeneity from human liver by a 3-step procedure including protamine sulfate/ammonium… Expand
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