FAQ

fatty-acid synthase activity

Known as: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing), lovastatin nonaketide synthase activity, acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) 
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2018
0519812018

Related topics

Related topics

1 relation
Fatty-acid synthase

Related mentions per year

Related mentions per year

1975-2018
197019801990200020102020
fatty-acid synthase activity
Fatty-acid synthase

Papers overview

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2010
2010
Macrophage-derived AIM is endocytosed into adipocytes and decreases lipid droplets via inhibition of fatty acid synthase activity.
Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the… (More)
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2005
2005
Insulin acutely decreases hepatic fatty acid synthase activity.
Insulin is viewed as a positive regulator of fatty acid synthesis by increasing fatty acid synthase (FAS) mRNA transcription. We… (More)
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Highly Cited
2005
Highly Cited
2005
Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity.
The consumption of food products containing high amounts of flavonoids has been reported to lower the risk of various cancers… (More)
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2002
2002
Effects of pyrazinamide on fatty acid synthesis by whole mycobacterial cells and purified fatty acid synthase I.
The effects of low extracellular pH and intracellular accumulation of weak organic acids were compared with respect to fatty acid… (More)
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Highly Cited
2001
Highly Cited
2001
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
Fatty acid synthetic metabolism is abnormally elevated in tumor cells, and pharmacological inhibitors of the anabolic enzyme… (More)
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Highly Cited
2001
Highly Cited
2001
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance.
Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The… (More)
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1998
1998
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
The aim of this study was to evaluate the chronic effects of a short-chain fructo-oligosaccharide (FOS)-containing diet on plasma… (More)
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1993
1993
Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability.
Carbohydrate feeding of animals results in striking increases in hepatic fatty acid synthesis but much of this induction is… (More)
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Highly Cited
1993
Highly Cited
1993
Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation.
1. Viable myocytes were obtained from rat hearts. Oxidation of [1-14C]palmitate by these cells could be decreased by the addition… (More)
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1986
1986
Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase.
Fatty-acid synthase has been purified to homogeneity from human liver by a 3-step procedure including protamine sulfate/ammonium… (More)
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