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fatty-acid synthase activity

Known as: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing), lovastatin nonaketide synthase activity, acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) 
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9… 
National Institutes of Health

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Fatty-acid synthase

Papers overview

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Highly Cited
2010
Highly Cited
2010
Inhibitory effects of ursolic acid on hepatic polyol pathway and glucose production in streptozotocin-induced diabetic mice.
Highly Cited
2008
Highly Cited
2008
Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice.
Highly Cited
2005
Highly Cited
2005
Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity*
The consumption of food products containing high amounts of flavonoids has been reported to lower the risk of various cancers… 
Highly Cited
2002
Highly Cited
2002
Effects of Pyrazinamide on Fatty Acid Synthesis by Whole Mycobacterial Cells and Purified Fatty Acid Synthase I
ABSTRACT The effects of low extracellular pH and intracellular accumulation of weak organic acids were compared with respect to… 
Highly Cited
2001
Highly Cited
2001
Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.
Fatty acid synthetic metabolism is abnormally elevated in tumor cells, and pharmacological inhibitors of the anabolic enzyme… 
Highly Cited
2001
Highly Cited
2001
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance.
Obesity and dysfunctional energy partitioning can lead to the development of insulin resistance and type 2 diabetes. The… 
Highly Cited
1999
Highly Cited
1999
Catalytic enantioselective Michael additions to unsaturated ester derivatives using chiral copper(II) Lewis acid complexes.
[formula: see text] Chiral Cu(II) bisoxazoline (box) Lewis acids have been developed as catalysts of the Michael addition of… 
Highly Cited
1998
Highly Cited
1998
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
The aim of this study was to evaluate the chronic effects of a short-chain fructo-oligosaccharide (FOS)-containing diet on plasma… 
Highly Cited
1993
Highly Cited
1993
Malonyl-CoA metabolism in cardiac myocytes and its relevance to the control of fatty acid oxidation.
1. Viable myocytes were obtained from rat hearts. Oxidation of [1-14C]palmitate by these cells could be decreased by the addition… 
Highly Cited
1986
Highly Cited
1986
Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase.
Fatty-acid synthase has been purified to homogeneity from human liver by a 3-step procedure including protamine sulfate/ammonium… 
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