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fatty-acid synthase activity

Known as: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing), lovastatin nonaketide synthase activity, acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) 
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the… Expand
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Highly Cited
2005
Highly Cited
2005
The consumption of food products containing high amounts of flavonoids has been reported to lower the risk of various cancers… Expand
Highly Cited
2005
Highly Cited
2005
Insulin is viewed as a positive regulator of fatty acid synthesis by increasing fatty acid synthase (FAS) mRNA transcription. We… Expand
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Highly Cited
2002
Highly Cited
2002
The effects of low extracellular pH and intracellular accumulation of weak organic acids were compared with respect to fatty acid… Expand
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Highly Cited
2001
Highly Cited
2001
Fatty acid synthetic metabolism is abnormally elevated in tumor cells, and pharmacological inhibitors of the anabolic enzyme… Expand
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Highly Cited
1999
Highly Cited
1999
[formula: see text] Chiral Cu(II) bisoxazoline (box) Lewis acids have been developed as catalysts of the Michael addition of… Expand
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Highly Cited
1998
Highly Cited
1998
The aim of this study was to evaluate the chronic effects of a short-chain fructo-oligosaccharide (FOS)-containing diet on plasma… Expand
Highly Cited
1993
Highly Cited
1993
1. Viable myocytes were obtained from rat hearts. Oxidation of [1-14C]palmitate by these cells could be decreased by the addition… Expand
Highly Cited
1993
Highly Cited
1993
Carbohydrate feeding of animals results in striking increases in hepatic fatty acid synthesis but much of this induction is… Expand
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Highly Cited
1986
Highly Cited
1986
Fatty-acid synthase has been purified to homogeneity from human liver by a 3-step procedure including protamine sulfate/ammonium… Expand