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fatty-acid synthase activity

Known as: acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing), lovastatin nonaketide synthase activity, acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing, thioester-hydrolysing) 
Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Macrophages infiltrate adipose tissue in obesity and are involved in the induction of inflammation, thereby contributing to the… Expand
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Highly Cited
2005
Highly Cited
2005
The consumption of food products containing high amounts of flavonoids has been reported to lower the risk of various cancers… Expand
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Highly Cited
2005
Highly Cited
2005
Insulin is viewed as a positive regulator of fatty acid synthesis by increasing fatty acid synthase (FAS) mRNA transcription. We… Expand
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Highly Cited
2002
Highly Cited
2002
The effects of low extracellular pH and intracellular accumulation of weak organic acids were compared with respect to fatty acid… Expand
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Highly Cited
2001
Highly Cited
2001
Fatty acid synthetic metabolism is abnormally elevated in tumor cells, and pharmacological inhibitors of the anabolic enzyme… Expand
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Highly Cited
2001
Highly Cited
2001
White adipose tissue is known to contain the components of the renin-angiotensin system, which gives rise to angiotensin II from… Expand
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1998
1998
The aim of this study was to evaluate the chronic effects of a short-chain fructo-oligosaccharide (FOS)-containing diet on plasma… Expand
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Highly Cited
1993
Highly Cited
1993
1. Viable myocytes were obtained from rat hearts. Oxidation of [1-14C]palmitate by these cells could be decreased by the addition… Expand
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1993
1993
Carbohydrate feeding of animals results in striking increases in hepatic fatty acid synthesis but much of this induction is… Expand
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Highly Cited
1986
Highly Cited
1986
Fatty-acid synthase has been purified to homogeneity from human liver by a 3-step procedure including protamine sulfate/ammonium… Expand
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