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falcipain 2

Known as: falcipain-2 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Cysteine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Inhibition of Plasmodium falciparum cysteine proteases by the sugarcane cystatin CaneCPI-4.
2016
2016
Characterization of a papain-like cysteine protease essential for the survival of Babesia ovis merozoites.
2014
2014
Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.
2014
2014
Methyl-methoxylpyrrolinone and flavinium nucleus binding signatures on falcipain-2 active site
Following the increasing reports of human toxicity and plasmodium resistance to artemisinin and its derivatives, falcipain-2 (FP… 
2011
2011
Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.
2011
2011
Peptidomimetic nitriles as selective inhibitors for the malarial cysteine protease falcipain-2
Proteases of protozoan parasites have emerged as promising targets in drug design and discovery due to their indispensable roles… 
2010
2010
Antimalarial activity of azadipeptide nitriles.
Highly Cited
2009
Highly Cited
2009
Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.
This paper describes the synthesis and biological evaluation of a new class of peptidomimetic falcipain-2 inhibitors based on a 1… 
Highly Cited
2003
Highly Cited
2003
Antimalarial Activities of Novel Synthetic Cysteine Protease Inhibitors
ABSTRACT Among promising new targets for antimalarial chemotherapy are the cysteine protease hemoglobinases falcipain-2 and… 
2002
2002
Homology Modeling of Falcipain-2: Validation, De Novo Ligand Design and Synthesis of Novel Inhibitors
Abstract Increasing resistance of malaria parasites, in particular Plasmodiun falciparum, demands a serious search for novel… 
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