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American Association for the Study of Liver Diseases
- P. Rosenthal
- Medicine, BiologyIDrugs : the investigational drugs journal
- 1 October 1993
The latest advances in hepatology were presented in oral and poster presentations, focused on treatments for viral hepatitis, autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis, and recurrent viral disease following liver transplant.
Antimalarial drug discovery: efficacy models for compound screening
- D. Fidock, P. Rosenthal, S. Croft, R. Brun, S. Nwaka
- Biology, MedicineNature Reviews Drug Discovery
- 1 June 2004
Different in vitro and in vivo screens for antimalarial drug discovery are suggested and a streamlined process for evaluating new compounds on the path from drug discovery to development is recommended.
Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group.
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
In pregnancy, quinine continues to play a critical role in the management of malaria, especially in the first trimester, and it will remain a mainstay of treatment until safer alternatives become available.
Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study.
An assay to quantify rare polymorphisms in parasite populations that uses a pooled deep-sequencing approach to score allele frequencies is developed and validated by evaluating mixtures of laboratory parasite strains, and used to screen P. falciparum parasites from >1100 African infections collected since 2002.
Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.
Neither vitamin E nor metformin was superior to placebo in attaining the primary outcome of sustained reduction in ALT level in patients with pediatric NAFLD.
Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children
The prevalence of K13-propeller and FP2 polymorphisms did not increase over time, and was not associated with either time since prior receipt of an ACT or the persistence of parasites ≥2 days following treatment with an ACT, indicating that artemisinin resistance is not prevalent in Uganda.
Cysteine proteases of malaria parasites.
- P. Rosenthal
- Biology, MedicineInternational journal for parasitology
- 1 December 2004
NASPGHAN practice guidelines: Diagnosis and management of hepatitis C infection in infants, children, and adolescents.
- C. Mack, R. González-Peralta, K. Schwarz
- Medicine, BiologyJournal of pediatric gastroenterology and…
- 1 June 2012
The guideline details the epidemiology and natural history of HCV infection in children, the diagnostic workup, monitoring and treatment of disease, and provides an update on future treatment options and areas of research.
Antimalarial drug discovery: old and new approaches
- P. Rosenthal
- Biology, MedicineJournal of Experimental Biology
- 1 November 2003
A number of new antimalarial therapies will likely be needed over the coming years, so it is important to pursue multiple strategies for drug discovery.