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exochelin MN

National Institutes of Health

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Cyclic Peptides

Papers overview

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2002
2002
Total synthesis of exochelin MN and analogues.
The first total synthesis of exochelin MN is described along with rationally designed analogues. The required L-threo-beta… 
2002
2002
A mycobacterial iron chelator, desferri-exochelin, induces hypoxia-inducible factors 1 and 2, NIP3, and vascular endothelial growth factor in cancer cell lines.
Hypoxia is a key phenomenon in tumor behavior, selecting for resistance to apoptosis, conferring resistance to radiotherapy and… 
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