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In this critical review, the ring opening of non-activated 2-substituted aziridines via intermediate aziridinium salts will be… Expand The development of biotech drugs such as peptides and proteins that act in the central nervous system has been significantly… Expand Activity-dependent neurotrophic factor (ADNF) is a glia-derived protein that is neuroprotective at femtomolar concentrations. A… Expand The involvement of nitric oxide in neurodegenerative processes still remains incompletely characterized. Although nitric oxide… Expand Neurodegenerative diseases, in which neuronal cell disintegrate, bring about deteriorations in cognitive functions as is… Expand The time course of the cholinotoxicity of ethylcholine aziridinium ion (AF64A) has been investigated. Rats were injected with… Expand The present study examined the nature of the cognitive deficits associated with a selective decrease of cholinergic activity in… Expand Ethylcholine aziridinium ion solution (AF64A), a putative specific cholinergic neurotoxin, was injected bilaterally into the… Expand AF64A is a toxin which can diminish irreversibly cholinergic transmission in vivo (1, 2). Disruption of neurotransmitter function… Expand Ethylcholine mustard aziridinium ion (AF64A), a neurotoxic choline analog, was evaluated for its interactions with the… Expand