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estrogen receptor alpha, human

Known as: Estrogen Receptor 1, Estradiol Receptor, ESR1 protein, human 
A protein found inside the cells of the female reproductive tissue, some other types of tissue, and some cancer cells. The hormone estrogen will bind… 
National Institutes of Health

Related topics

Related topics

36 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation

Broader (3)

Estrogen Receptor 1Estrogen Receptor alphaEstrogen Receptors

Narrower (1)

estrogen receptor alpha isoform S, human

Papers overview

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Highly Cited
2003
Highly Cited
2003
Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases.
PURPOSE To determine whether progesterone receptor (PgR) status provides additional value to estrogen receptor (ER) status and… 
Review
2001
Review
2001
Role of estrogen receptor beta in estrogen action.
There was a time when the classification of sex hormones was simple. Androgens were male and estrogens female. What remains true… 
Highly Cited
2000
Highly Cited
2000
Technical advance: An estrogen receptor-based transactivator XVE mediates highly inducible gene expression in transgenic plants.
We have developed an estrogen receptor-based chemical-inducible system for use in transgenic plants. A chimeric transcription… 
Review
2000
Review
2000
Aberrant methylation of the estrogen receptor and E-cadherin 5' CpG islands increases with malignant progression in human breast cancer.
Loss of expression for both the estrogen receptor-alpha and E-cadherin genes has been linked to disease progression in human… 
Highly Cited
1999
Highly Cited
1999
Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor.
The effectiveness of estrogens in stimulating gene transcription mediated by the estrogen receptor (ER) appears to depend on ER… 
Highly Cited
1995
Highly Cited
1995
Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.
A conserved region in the hormone‐dependent activation domain AF2 of nuclear receptors plays an important role in transcriptional… 
Highly Cited
1994
Highly Cited
1994
Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions.
We have used a series of human estrogen receptor (ER) mutants to evaluate the cell- and promoter-specific transcriptional… 
Highly Cited
1993
Highly Cited
1993
The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements
Highly Cited
1989
Highly Cited
1989
The human estrogen receptor has two independent nonacidic transcriptional activation functions
Highly Cited
1980
Highly Cited
1980
Monoclonal antibodies to human estrogen receptor.
Extranuclear estrogen receptor protein (estrophilin) of MCF-7 human breast cancer cells was purified by passage of the cytosol… 
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