The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

@article{Schwabe1993TheCS,
  title={The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements},
  author={J. Schwabe and L. Chapman and J. Finch and D. Rhodes},
  journal={Cell},
  year={1993},
  volume={75},
  pages={567-578}
}
The nuclear hormone receptors are a superfamily of ligand-activated DNA-binding transcription factors. We have determined the crystal structure (at 2.4 A) of the fully specific complex between the DNA-binding domain from the estrogen receptor and DNA. The protein binds as a symmetrical dimer to its palindromic binding site consisting of two 6 bp consensus half sites with three intervening base pairs. This structure reveals how the protein recognizes its own half site sequence rather than that… Expand
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