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esorubicin

Known as: 4-desoxydoxorubicin, Deoxydoxorubicin, 4'-Deoxyadriamycin 
A synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin with potential antineoplastic activity. Esorubicin intercalates… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antibiotics, AntineoplasticDoxorubicin

Narrower (1)

IMI 58
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines.
The antimalarial artemisinins also reveal profound cytotoxic activity against tumor cells. Artemisinins harbor an endoperoxide… 
Highly Cited
1990
Highly Cited
1990
Mechanisms of resistance of confluent human and rat colon cancer cells to anthracyclines: alteration of drug passive diffusion.
Two colon cancer cell lines, HT-29 (human) and DHD/K12/TRb (rat), were grown as monolayer cultures to various confluence degrees… 
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Highly Cited
1986
Highly Cited
1986
Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells.
We have produced adriamycin (ADM)-resistant variants of the human lung cancer cell lines NCI-H69 (small cell), MOR… 
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Highly Cited
1986
Highly Cited
1986
Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by non-small cell lung tumor cells in culture and its relationship to cell survival.
4'-Deoxydoxorubicin (4'-deoxy) is a new adriamycin analogue with a similar spectrum of antitumour activity but is significantly… 
Highly Cited
1984
Highly Cited
1984
Self-association of doxorubicin and related compounds in aqueous solution.
The dimerization of doxorubicin, daunorubicin, and their 4-demethoxy, 4'-epi, and 4'-deoxy analogues was studied… 
Highly Cited
1984
Highly Cited
1984
Metabolism of 4'-modified analogs of doxorubicin. unique glucuronidation pathway for 4'-epidoxorubicin.
The metabolism of doxorubicin (A), 4'-epidoxorubicin (E) and 4'-deoxydoxorubicin (D) was studied in vitro by incubating the… 
Highly Cited
1980
Highly Cited
1980
New doxorubicin analogs active against doxorubicin-resistant colon tumor xenografts in the nude mouse.
The antitumor activity of doxorubicin and three new derivatives modified on the position 4' of the amino sugar was tested against… 
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Highly Cited
1977
Highly Cited
1977
Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function.
A new, nondestructive, plasma extraction technique ultilizing chloroform:isopropyl alcohol (1:1) and ammonium sulfate saturation… 
Highly Cited
1976
Highly Cited
1976
Adriamycin metabolism in man. Evidence from urinary metabolites.
We studied the human metabolism of adriamycin by isolating and identifying urinary metabolites which retain adriamycin's specific… 
Highly Cited
1976
Highly Cited
1976
Synthesis and antitumor activity of 4'-deoxydaunorubicin and 4'-deoxyadriamycin.
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