erad

Known as: ER-associated protein breakdown, ER-associated ubiquitin-dependent protein catabolic process, endoplasmic reticulum-associated protein catabolic process 
The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic… (More)

Topic mentions per year

Topic mentions per year

1976-2018
020406019762018

Papers overview

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Highly Cited
2011
Highly Cited
2011
Proteins that fail to correctly fold or assemble into oligomeric complexes in the endoplasmic reticulum (ER) are degraded by a… (More)
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Highly Cited
2009
Highly Cited
2009
Many apicomplexan parasites, including Plasmodium falciparum, harbor a so-called apicoplast, a complex plastid of red algal… (More)
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2007
2007
Secretory proteins unable to assemble into their native states in the endoplasmic reticulum (ER) are transported back or… (More)
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Highly Cited
2006
Highly Cited
2006
Bernd Bukau,1 Jonathan Weissman,2 and Arthur Horwich3,4,* 1Zentrum fur Molekulare Biologie, Universität Heidelberg, 69120… (More)
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Highly Cited
2006
Highly Cited
2006
The AAA-ATPase p97/VCP facilitates protein dislocation during endoplasmic reticulum-associated degradation (ERAD). To understand… (More)
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Highly Cited
2005
Highly Cited
2005
Endoplasmic reticulum (ER)-associated protein degradation (ERAD) is a quality control system that removes misfolded proteins from… (More)
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Highly Cited
2003
Highly Cited
2003
The endoplasmic reticulum (ER) harbors a protein quality control system, which monitors protein folding in the ER. Elimination of… (More)
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Highly Cited
2000
Highly Cited
2000
The unfolded protein response (UPR) regulates gene expression in response to stress in the endoplasmic reticulum (ER). We… (More)
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Highly Cited
2000
Highly Cited
2000
Ubiquitin conjugation during endoplasmic-reticulum-associated degradation (ERAD) depends on the activity of Ubc7. Here we show… (More)
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Highly Cited
1996
Highly Cited
1996
To investigate the mechanisms of ER-associated protein degradation (ERAD), this process was reconstituted in vitro. Established… (More)
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