Skip to search formSkip to main contentSkip to account menu

Endoplasmic Reticulum-Associated Degradation

Known as: Pathway, ERAD, Reticulum-Associated Degradation, Endoplasmic, Degradation, Endoplasmic Reticulum-Associated 
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with… 
National Institutes of Health

Related topics

Related topics

8 relations
Endoplasmic Reticulum StressProteolysisUbiquitinationaspects of radiation effects

Narrower (1)

erad

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Expression of rabies virus glycoprotein in the methylotrophic yeast Pichia pastoris
Rabies is a fatal disease that can be prevented by vaccination. Different approaches were investigated to develop novel human… 
2013
2013
Unfolded Protein Response and Activated Degradative Pathways Regulation in GNE Myopathy
Although intracellular beta amyloid (Aβ) accumulation is known as an early upstream event in the degenerative course of UDP-N… 
2013
2013
SEL1L Regulates Adhesion, Proliferation and Secretion of Insulin by Affecting Integrin Signaling
SEL1L, a component of the endoplasmic reticulum associated degradation (ERAD) pathway, has been reported to regulate the (i… 
2012
2012
Using a ubiquitin ligase as an unfolded protein sensor.
Review
2011
Review
2011
The complexities of p97 function in health and disease.
p97 is a homohexameric, toroidal machine that harnesses the energy of ATP binding and hydrolysis to effect structural… 
2010
2010
Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation
Int6/eIF3e is implicated in tumorigenesis, but its molecular functions remain unclear. We have studied its fission yeast homolog… 
2009
2009
Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells.
Cytochrome P450 2C9 (P450 2C9) is one of the most important P450 isoforms in the human liver, as it metabolizes numerous… 
2008
2008
Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system.
2008
2008
SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig‐µ chains
When expressed in the absence of light chains, secretory Ig‐µ chains (µs) undergo endoplasmic reticulum associated degradation… 
2007
2007
Tipping the Delicate Balance: Defining How Proteasome Maturation Affects the Degradation of a Substrate for Autophagy and Endoplasmic Reticulum Associated Degradation (ERAD)
An increasing body of data links endoplasmic reticulum (ER) function to autophagy. Not surprisingly, then, some aberrant proteins… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)