Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Endoplasmic Reticulum-Associated Degradation

Known as: Pathway, ERAD, Reticulum-Associated Degradation, Endoplasmic, Degradation, Endoplasmic Reticulum-Associated 
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with… Expand
National Institutes of Health

Related topics

Related topics

8 relations
Endoplasmic Reticulum StressProteolysisUbiquitinationaspects of radiation effects
Expand

Narrower (1)

erad

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions
Neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease (HD), amyotrophic… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
2018
2018
Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches
Autosomal recessive loss-of-function mutations in N-glycanase 1 (NGLY1) cause NGLY1 deficiency, the only known human disease of… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • table 3
2013
2013
A unique IBMPFD-related P97/VCP mutation with differential binding pattern and subcellular localization.
p97/VCP is a hexameric AAA type ATPase that functions in a variety of cellular processes such as endoplasmic reticulum associated… Expand
  • figure 3
  • figure 5
  • figure 6
2012
2012
Tyrosinase Degradation Is Prevented when EDEM1 Lacks the Intrinsically Disordered Region
EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to… Expand
  • figure 4
  • figure 5
2011
2011
Identification and characterization of peptide: N- glycanase from Dictyostelium discoideum
BackgroundPeptide: N- glycanase (PNGase) enzyme cleaves oligosaccharides from the misfolded glycoproteins and prepares them for… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2010
Highly Cited
2010
The NF-kappaB signaling in cystic fibrosis lung disease: pathophysiology and therapeutic potential.
Lung disease is the major cause of morbidity and mortality of cystic fibrosis (CF), an autosomal recessive disease caused by… Expand
2009
2009
Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein
Abstract The presence of two basic amino acids strategically located within a single spanning transmembrane region has previously… Expand
2008
2008
SEL1L and HRD1 are involved in the degradation of unassembled secretory Ig‐µ chains
When expressed in the absence of light chains, secretory Ig‐µ chains (µs) undergo endoplasmic reticulum associated degradation… Expand
2008
2008
Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system.
The 52-kDa form of SSA/Ro protein (Ro52) is one of autoantigens associated with autoimmune disorders such as systemic lupus… Expand
2007
2007
Tipping the Delicate Balance: Defining How Proteasome Maturation Affects the Degradation of a Substrate for Autophagy and Endoplasmic Reticulum Associated Degradation (ERAD)
An increasing body of data links endoplasmic reticulum (ER) function to autophagy. Not surprisingly, then, some aberrant proteins… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE