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Endoplasmic Reticulum-Associated Degradation

Known as: Pathway, ERAD, Reticulum-Associated Degradation, Endoplasmic, Degradation, Endoplasmic Reticulum-Associated 
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease (HD), amyotrophic… Expand
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2018
2018
Autosomal recessive loss-of-function mutations in N-glycanase 1 (NGLY1) cause NGLY1 deficiency, the only known human disease of… Expand
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2013
2013
p97/VCP is a hexameric AAA type ATPase that functions in a variety of cellular processes such as endoplasmic reticulum associated… Expand
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2012
2012
EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to… Expand
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2011
2011
BackgroundPeptide: N- glycanase (PNGase) enzyme cleaves oligosaccharides from the misfolded glycoproteins and prepares them for… Expand
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Highly Cited
2010
Highly Cited
2010
Lung disease is the major cause of morbidity and mortality of cystic fibrosis (CF), an autosomal recessive disease caused by… Expand
2009
2009
Abstract The presence of two basic amino acids strategically located within a single spanning transmembrane region has previously… Expand
2008
2008
When expressed in the absence of light chains, secretory Ig‐µ chains (µs) undergo endoplasmic reticulum associated degradation… Expand
2008
2008
The 52-kDa form of SSA/Ro protein (Ro52) is one of autoantigens associated with autoimmune disorders such as systemic lupus… Expand
2007
2007
An increasing body of data links endoplasmic reticulum (ER) function to autophagy. Not surprisingly, then, some aberrant proteins… Expand