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efonidipine

Known as: 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl ester, P-oxide, monohydrochloride, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-(phenyl(phenylmethyl)amino) ethyl ester, P-oxide, hydrochloride 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (7)

Antihypertensive AgentsCalcium Channel BlockersDihydropyridinesDiuretics
Efonidipine Hydrochloride

Narrower (2)

NZ 105enfonidipine hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Five different profiles of dihydropyridines in blocking T-type Ca(2+) channel subtypes (Ca(v)3.1 (alpha(1G)), Ca(v)3.2 (alpha(1H)), and Ca(v)3.3 (alpha(1I))) expressed in Xenopus oocytes.
2008
2008
T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers.
Review
2007
Review
2007
Ca2+ channel subtypes and pharmacology in the kidney.
A large body of evidence has accrued indicating that voltage-gated Ca(2+) channel subtypes, including L-, T-, N-, and P/Q-type… 
2006
2006
Actions of Mibefradil, Efonidipine and Nifedipine Block of Recombinant T- and L-Type Ca2+ Channels with Distinct Inhibitory Mechanisms
We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues, and mibefradil using recombinant T- and L… 
2006
2006
Inhibitory Effect of Efonidipine on Aldosterone Synthesis and Secretion in Human Adrenocarcinoma (H295R) Cells
Targeting aldosterone synthesis and/or release represents a potentially useful approach to the prevention of cardiovascular… 
Highly Cited
2004
Highly Cited
2004
Identification of R(−)‐isomer of efonidipine as a selective blocker of T‐type Ca2+ channels
Efonidipine, a derivative of dihydropyridine Ca2+ antagonist, is known to block both L‐ and T‐type Ca2+ channels. It remains to… 
Highly Cited
2003
Highly Cited
2003
Nongenomic vascular action of aldosterone in the glomerular microcirculation.
Aldosterone (Aldo) accelerates hypertension, proteinuria, and glomerulosclerosis in animal models of malignant hypertension or… 
Highly Cited
2002
Highly Cited
2002
Effects of efonidipine on platelet and monocyte activation markers in hypertensive patients with and without type 2 diabetes mellitus
We compared the levels of microparticles, platelet activation markers, soluble cell adhesion molecules, and soluble selectins… 
Highly Cited
2002
Highly Cited
2002
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
2000
2000
Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats.
The influence of hypertension and of treatment with some dihydropyridine-type Ca(2+) channel blockers and with the… 
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