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efonidipine

Known as: 3-Pyridinecarboxylic acid, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(phenyl(phenylmethyl)amino)ethyl ester, P-oxide, monohydrochloride, 5-(5,5-dimethyl-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic acid, 2-(phenyl(phenylmethyl)amino) ethyl ester, P-oxide, hydrochloride 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (7)

Antihypertensive AgentsCalcium Channel BlockersDihydropyridinesDiuretics
Efonidipine Hydrochloride

Narrower (2)

NZ 105enfonidipine hydrochloride

Papers overview

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2010
2010
Angiotensin II regulates endothelial cell migration through calcium influx via T‐type calcium channel in human umbilical vein endothelial cells
Aim:  The T‐type calcium channel is expressed in vascular endothelial cells, but its role in endothelial cell function is yet to… 
2009
2009
Five different profiles of dihydropyridines in blocking T-type Ca(2+) channel subtypes (Ca(v)3.1 (alpha(1G)), Ca(v)3.2 (alpha(1H)), and Ca(v)3.3 (alpha(1I))) expressed in Xenopus oocytes.
2007
2007
Comparison of the Effects of Efonidipine and Amlodipine on Aldosterone in Patients with Hypertension
To prevent cardiovascular disease, targeting aldosterone synthesis and release may be clinically important. Aldosterone… 
2007
2007
Efonidipine Reduces Proteinuria and Plasma Aldosterone in Patients with Chronic Glomerulonephritis
Efonidipine, a dihydropirydine calcium channel blocker, has been shown to dilate the efferent glomerular arterioles as… 
2006
2006
Inhibitory Effect of Efonidipine on Aldosterone Synthesis and Secretion in Human Adrenocarcinoma (H295R) Cells
Targeting aldosterone synthesis and/or release represents a potentially useful approach to the prevention of cardiovascular… 
2006
2006
Blocking T-Type Ca2+ Channels with Efonidipine Decreased Plasma Aldosterone Concentration in Healthy Volunteers
Efonidipine can block both L- and T- type Ca2+ channels. In a previous in vitro study, we clarified that efonidipine dramatically… 
Highly Cited
2004
Highly Cited
2004
Identification of R(−)‐isomer of efonidipine as a selective blocker of T‐type Ca2+ channels
Efonidipine, a derivative of dihydropyridine Ca2+ antagonist, is known to block both L‐ and T‐type Ca2+ channels. It remains to… 
Highly Cited
2001
Highly Cited
2001
Effect of T-Type Selective Calcium Antagonist on Renal Microcirculation: Studies in the Isolated Perfused Hydronephrotic Kidney
Although calcium antagonists exert preferential vasodilation of renal afferent arterioles, we have recently demonstrated that… 
1998
1998
Renal protective effects of efonidipine in partially nephrectomized spontaneously hypertensive rats.
We investigated the effects of a calcium antagonist, efonidipine, which was reported to dilate not only afferent arterioles but… 
Review
1998
Review
1998
Current status of calcium antagonists in Japan.
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