efalizumab

Known as: anti alphaL integrin, antiCD11 alpha, efalizumab [Chemical/Ingredient] 
A humanized IgG1 monoclonal antibody directed against CD11a, the alpha subunit of human leukocyte-function-associated antigen type 1 (LFA-1), with… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2017
05010019752017

Papers overview

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2011
2011
BACKGROUND Progressive multifocal leukoencephalopathy (PML), a rare, potentially fatal demyelinating disease, affects primarily… (More)
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2009
2009
In April 2009, efalizumab was withdrawn from the market for the treatment of psoriasis after reports emerged of an association… (More)
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2007
2007
BACKGROUND Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis. Efalizumab, a T cell-targeted… (More)
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2006
2006
BACKGROUND Efalizumab (anti-CD11a), a humanized monoclonal antibody, blocks multiple T-cell-dependent functions implicated in the… (More)
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Highly Cited
2005
Highly Cited
2005
We find that CD11c(+) cells with many markers of dendritic cells (DCs) are a major cell type in the skin lesions of psoriasis… (More)
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2005
2005
BACKGROUND Efalizumab inhibits multiple T-cell-mediated processes. OBJECTIVE To evaluate 12- and 24-week efalizumab therapy for… (More)
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2005
2005
Efalizumab is a humanized anti-CD11a monoclonal antibody that demonstrated efficacy in the treatment of patients with psoriasis… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Interactions between leukocyte-function-associated antigen type 1 (LFA-1) and intercellular adhesion molecules are… (More)
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Highly Cited
2003
Highly Cited
2003
CONTEXT Because T-cell interactions are involved in the pathophysiology of psoriasis, therapy with a T-cell modulator may have… (More)
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Highly Cited
1975
Highly Cited
1975
Methods for the cultivation of erythroid colonies in vitro are expected to allow selective assay of the earliest committed… (More)
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