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efalizumab

Known as: anti alphaL integrin, antiCD11 alpha, efalizumab [Chemical/Ingredient] 
A humanized IgG1 monoclonal antibody directed against CD11a, the alpha subunit of human leukocyte-function-associated antigen type 1 (LFA-1), with… 
National Institutes of Health

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Monoclonal Antibodiesantigen bindinghu1124

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Raptiva

Papers overview

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Highly Cited
2013
Highly Cited
2013
PML in a patient treated with dimethyl fumarate from a compounding pharmacy.
Two cases of progressive multifocal leukoencephalopathy (PML) are reported in patients with psoriasis who were treated with… 
Highly Cited
2012
Highly Cited
2012
Fatal PML associated with efalizumab therapy
Objectives: Progressive multifocal leukoencephalopathy (PML) has become much more common with monoclonal antibody treatment for… 
Highly Cited
2012
Highly Cited
2012
Marketed therapeutic antibodies compendium
Therapeutic monoclonal antibodies (mAbs) are currently being approved for marketing in Europe and the United States, as well as… 
Review
2010
Review
2010
Progressive multifocal leukoencephalopathy in patients on immunomodulatory therapies.
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the white matter of the human brain caused by… 
Review
2009
Review
2009
Treatments for psoriasis and the risk of malignancy.
Review
2009
Review
2009
Therapeutic monoclonal antibodies in ophthalmology
Highly Cited
2004
Highly Cited
2004
A 50% reduction in the Psoriasis Area and Severity Index (PASI 50) is a clinically significant endpoint in the assessment of psoriasis.
Highly Cited
2003
Highly Cited
2003
Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array.
A global picture of gene expression in the common immune-mediated skin disease, psoriasis, was obtained by interrogating the full… 
Highly Cited
2002
Highly Cited
2002
Psoriasis as a model for T-cell-mediated disease: immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a antibody.
BACKGROUND Leukocyte function-associated antigen 1 (LFA-1), consisting of CD11a and CD18 subunits, plays an important role in T… 
Highly Cited
1975
Highly Cited
1975
Erythroid progenitors in mouse bone marrow detected by macroscopic colony formation in culture.
Methods for the cultivation of erythroid colonies in vitro are expected to allow selective assay of the earliest committed… 
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