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Background: The fungus Aspergillus fumigatus causes human diseases that are treated with CYP51 azole inhibitors. Results: We… Expand CYP51 encodes the cytochrome P450 sterol 14α-demethylase, an enzyme essential for sterol biosynthesis and the target of azole… Expand ABSTRACT Aspergillus fumigatus sterol 14-α demethylase (CYP51) isoenzymes A (AF51A) and B (AF51B) were expressed in Escherichia… Expand ABSTRACT Purified Candida albicans sterol 14-α demethylase (CaCYP51) bound the CYP51 substrates lanosterol and eburicol… Expand SUMMARY Sterol demethylation inhibitors (DMIs) represent one of the largest groups of systemic fungicides that have been used to… Expand OBJECTIVES
The aim of this study was to identify changes in the gene expression profile of Candida albicans associated with the… Expand ABSTRACT The role of sterol mutations in the resistance of Candida albicans to antifungal agents has not been thoroughly… Expand Metabolism of lanosterol (LAN), 24‐methylene‐24,25‐dihydrolanosterol (24‐methyleneDHL), dihydrolanosterol (DHL) and obtusifoliol… Expand As in other pathogenic fungi, the major sterol synthesized by Cryptococcus neoformans var. neoformans is ergosterol. This yeast… Expand Candida albicans 6.4, which is resistant to both polyene and azole groups of antifungal antibiotics, has a larger lipid content… Expand