Biogenesis, molecular regulation and function of plant isoprenoids.
- F. Bouvier, A. Rahier, B. Camara
- BiologyProgress in lipid research
- 1 November 2005
Identification of natural RORγ ligands that regulate the development of lymphoid cells.
- F. R. Santori, Pengxiang Huang*, D. Littman
- BiologyCell Metabolism
- 3 February 2015
Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases.
Clear and distinct biochemical phenotypes demonstrate that, in contrast with animals and fungi, in photosynthetic eukaryotes, these two novel families of cDNAs are coding two distinct types of C-4-methylsterol oxidases controlling the level of 4,4-dimethylsterol and 4alpha- methylsterol precursors respectively.
Emopamil-binding Protein, a Mammalian Protein That Binds a Series of Structurally Diverse Neuroprotective Agents, Exhibits Δ8-Δ7 Sterol Isomerase Activity in Yeast*
The results strongly suggest that EBP and Δ8-Δ7 sterol isomerase are identical proteins in mammals.
The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae
- S. Silve, P. Leplatois, G. Loison
- Biology, ChemistryMolecular and Cellular Biology
- 1 June 1996
The results suggest that sterol isomerase is the target of SR 31747 and that both the SUR4 and FEN1 gene products are required to mediate the proliferation arrest induced by ergosterol depletion.
Characterization of Plant Carotenoid Cyclases as Members of the Flavoprotein Family Functioning with No Net Redox Change1[W][OA]
- A. S. Mialoundama, D. Heintz, F. Bouvier
- Chemistry, BiologyPlant Physiology
- 11 May 2010
The data herein reveal plant carotenoid cyclases to be novel enzymes that combine characteristics of non-metal-assisted terpene cyclases with those attributes typically found in flavoenzymes that catalyze reactions, with no net redox, such as type 2 isopentenyl diphosphate isomerase.
Inhibition of ergosterol biosynthesis by morpholine, piperidine, and spiroketalamine fungicides in Microdochium nivale : Effect on sterol composition and sterol Δ8 → Δ7-isomerase activity
These fungicides seemed to be very good inhibitors of the sterol Δ 8 → Δ 7 -isomerase inhibition assays in cell-free enzyme systems, which confirmed the hypothesis that M. nivale was very sensitive in in vivo laboratory assays to fenpropimorph and tridemorph.
Molecular and Enzymatic Characterizations of Novel Bifunctional 3β-Hydroxysteroid Dehydrogenases/C-4 Decarboxylases from Arabidopsis thaliana*
- A. Rahier, S. Darnet, F. Bouvier, B. Camara, M. Bard
- Biology, ChemistryJournal of Biological Chemistry
- 15 September 2006
Two cDNAs from Arabidopsis thaliana encoding bifunctional 3β-hydroxysteroid dehydrogenase/C-4 decarboxylases (3βHSD/D) involved in sterol synthesis are isolated, the first molecularly and functionally characterized HSDs from a short chain dehydrogen enzyme/reductase family in plants.
Optimized expression and catalytic properties of a wheat obtusifoliol 14α‐demethylase (CYP51) expressed in yeast
- F. Cabello-Hurtado, M. Taton, D. Werck-Reichhart
- Biology
- 1 June 1999
The wheat enzyme was expressed in yeast strains overexpressing different P450 reductases as a fusion with either yeast or plant (sorghum) membrane targeting sequences and the expression level was fivefold reduced, as the modified yeasts did not need supplementation with exogenous ergosterol and grew normally under aerobic conditions.
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