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Biogenesis, molecular regulation and function of plant isoprenoids.
The function and evolutionary implications of this metabolism are discussed in relation with seminal informations gathered from distantly but related organisms.
Identification of natural RORγ ligands that regulate the development of lymphoid cells.
It is shown that sterol lipids are necessary and sufficient to drive RORγt-dependent transcription and suggest that CBIs play a role in lymphocyte development potentially through regulation of R ORγt.
Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases.
Clear and distinct biochemical phenotypes demonstrate that, in contrast with animals and fungi, in photosynthetic eukaryotes, these two novel families of cDNAs are coding two distinct types of C-4-methylsterol oxidases controlling the level of 4,4-dimethylsterol and 4alpha- methylsterol precursors respectively.
Emopamil-binding Protein, a Mammalian Protein That Binds a Series of Structurally Diverse Neuroprotective Agents, Exhibits Δ8-Δ7 Sterol Isomerase Activity in Yeast*
- S. Silve, P. Dupuy, +7 authors G. Loison
- Biology, MedicineThe Journal of Biological Chemistry
- 13 September 1996
The results strongly suggest that EBP and Δ8-Δ7 sterol isomerase are identical proteins in mammals.
Inhibition of ergosterol biosynthesis by morpholine, piperidine, and spiroketalamine fungicides in Microdochium nivale : Effect on sterol composition and sterol Δ8 → Δ7-isomerase activity
These fungicides seemed to be very good inhibitors of the sterol Δ 8 → Δ 7 -isomerase inhibition assays in cell-free enzyme systems, which confirmed the hypothesis that M. nivale was very sensitive in in vivo laboratory assays to fenpropimorph and tridemorph.
The immunosuppressant SR 31747 blocks cell proliferation by inhibiting a steroid isomerase in Saccharomyces cerevisiae
- S. Silve, P. Leplatois, +11 authors G. Loison
- Biology, MedicineMolecular and cellular biology
- 1 June 1996
The results suggest that sterol isomerase is the target of SR 31747 and that both the SUR4 and FEN1 gene products are required to mediate the proliferation arrest induced by ergosterol depletion.
Optimized expression and catalytic properties of a wheat obtusifoliol 14α‐demethylase (CYP51) expressed in yeast
The wheat enzyme was expressed in yeast strains overexpressing different P450 reductases as a fusion with either yeast or plant (sorghum) membrane targeting sequences and the expression level was fivefold reduced, as the modified yeasts did not need supplementation with exogenous ergosterol and grew normally under aerobic conditions.
Fungicides as Tools in Studying Postsqualene Sterol Synthesis in Plants
Abstract A variety of fungicides have been found to interfere with plant sterol biosynthesis. They were shown to block the biosynthetic reactions in the conversion of cycloartenol to phytosterols.…
Dissecting the sterol C-4 demethylation process in higher plants. From structures and genes to catalytic mechanism
- A. Rahier
- Medicine, BiologySteroids
- 1 March 2011
These studies provided the first molecularly and functionally characterized HSDs from a short chain dehydrogenase/reductase family in plants, and the first data on 3-D molecular interactions of an enzyme of the postoxidosqualene cyclase sterol biosynthetic pathway with its substrate in animals, yeast and higher plants.
Molecular and Enzymatic Characterizations of Novel Bifunctional 3β-Hydroxysteroid Dehydrogenases/C-4 Decarboxylases from Arabidopsis thaliana*
- A. Rahier, S. Darnet, F. Bouvier, B. Camara, M. Bard
- Biology, MedicineJournal of Biological Chemistry
- 15 September 2006
Two cDNAs from Arabidopsis thaliana encoding bifunctional 3β-hydroxysteroid dehydrogenase/C-4 decarboxylases (3βHSD/D) involved in sterol synthesis are isolated, the first molecularly and functionally characterized HSDs from a short chain dehydrogen enzyme/reductase family in plants.