dynemicin Q
National Institutes of Health
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Enediynes exhibit promise as anti‐tumor drugs because of their ability to induce cell apoptosis. After undergoing Bergman…
A double-stranded DNA cleavage mechanism by a novel enediyne type antitumor antibiotic, dynemicin A, has been investigated…
The naturally occurring enediyne antibiotics are a unique class of antitumor drugs that combine reactive enediynes with…
We found here that dynemicin A effectively breaks DNA strands under alkaline pH condition. Binding of dynemicin A to double…
Molecular dynamics (MD) simulations to model possible reaction pathways of the dynemicin‐A‐DNA cleavage mechanism were performed…
We report here that the DNA strand scission by dynemicin A is not only sequence-specific but also conformation-specific. The salt…
Intermolecular molecular modeling calculations to determine the intercalation behavior of dynemicin-A with DNA were performed…