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draflazine

Known as: 1-Piperazineacetamide, 2-(aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-(5,5-bis(4-fluorophenyl)pentyl)-, 2-aminocarbonyl-N-(4-amino-2,6-dichlorophenyl)-4-(5,5-bis(4-fluorophenyl)-pentyl)-1-piperazineacetamide 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Cardiotonic AgentsPiperazinesPlatelet Aggregation Inhibitors

Narrower (1)

R 75 231

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
The anti-overactive bladder activity of KW-7158 is mediated by blocking equilibrative nucleoside transporter-1.
KW-7158 is a novel therapeutic candidate for treating overactive bladder (OAB) with a unique mode of action: suppression of… 
2001
2001
Effects of nucleoside transport inhibition on hepatosplanchnic perfusion, oxygen extraction capabilities, and TNF release during acute endotoxic shock.
We explored the effects of the nucleoside transport inhibitor draflazine on regional blood flow, O2 extraction capabilities, and… 
1999
1999
Elevated levels of endogenous adenosine alter metabolism and enhance reduction in contractile function during low-flow ischemia: associated changes in expression of Ca(2+)-ATPase and phospholamban.
Adenosine has several potentially cardioprotective effects including vasodilatation, reduction in heart rate and alterations in… 
1999
1999
Cardioprotective effects of adenosine transport inhibition during reversible ischaemia in patients with coronary artery disease.
BACKGROUND: Adenosine plays a major role in protecting ischaemic myocardium and may potentiate ischaemic preconditioning… 
1998
1998
Using an analogue of draflazine for treatment of pain.
The invention relates to the use of a nucleoxido transport inhibitor, more particularly compounds of formula ** **, a N-oxide, an… 
1997
1997
Importance of endogenous adenosine during ischemia and reperfusion in neonatal porcine hearts.
BACKGROUND Adenosine has several potentially cardioprotective effects. We hypothesized that the effects of endogenous adenosine… 
1996
1996
Nucleoside transport inhibition by draflazine in unstable coronary disease
Objectives In a randomised, double-blind, placebo controlled study, we evaluated the tolerability and safety of draflazine, a… 
1995
1995
High‐Grade Nucleoside Transport Inhibition Stimulates Ventilation in Humans
In 6 healthy male volunteers a placebo‐controlled, double‐blind, randomized, crossover trial was done to assess the effect of 1… 
1994
1994
Purine and pyrimidine metabolism: still a black box?
1993
1993
Role of nucleoside transport inhibition and endogenous adenosine in prevention of catecholamine induced death in rabbits.
OBJECTIVE R 75,231, a potent and specific nucleoside transport inhibitor, largely prevents cardiac damage and death in… 
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