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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
TLDR
The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock. Expand
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure
TLDR
A so-called sepsis-related organ failure assessment (SOFA) score is created to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients. Expand
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
TLDR
The Grades of Recommendation, Assessment, Development and Evaluation (GRADE) system was used to guide assessment of quality of evidence from high to very low and to determine the strength of recommendations. Expand
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2016
TLDR
Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality. Expand
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
TLDR
Evidence-based recommendations can be made regarding many aspects of the acute management of sepsis and septic shock that will hopefully translate into improved outcomes for the critically ill patient. Expand
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
TLDR
This document reflects a process whereby a group of experts and opinion leaders revisited the 1992 sepsis guidelines and found that apart from expanding the list of signs and symptoms of sepsi to reflect clinical bedside experience, no evidence exists to support a change to the definitions. Expand
Anemia and blood transfusion in critically ill patients.
TLDR
This multicenter observational study reveals the common occurrence of anemia and the large use of blood transfusion in critically ill patients and provides evidence of an association between transfusions and diminished organ function as well as between transfusion and mortality. Expand
Efficacy and safety of recombinant human activated protein C for severe sepsis.
TLDR
Treatment with drotrecogin alfa activated significantly reduces mortality in patients with severe sepsis and may be associated with an increased risk of bleeding. Expand
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
TLDR
A hypothetical model for staging sepsis is presented, which, in the future, may better characterize the syndrome on the basis of predisposing factors and premorbid conditions, the nature of the underlying infection, the characteristics of the host response, and the extent of the resultant organ dysfunction. Expand
Serial evaluation of the SOFA score to predict outcome in critically ill patients.
CONTEXT Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome. OBJECTIVE To determine the usefulness of repeated measurement the Sequential Organ FailureExpand
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