dolutegravir

Known as: 2H-Pyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazine-9-carboxamide, N-((2,4-difluorophenyl)methyl)-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, (4R,12aS), (4R,9aS)-5-hydroxy-2-methyl-6,10-dioxo-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-7-carboxylic acid- 2,4 difluorobenzylamide, DTG 
An orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2018
05010015019592018

Papers overview

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Highly Cited
2014
Highly Cited
2014
This July 2014 edition of the IAS–USA drug resistance mutations list updates the figures last published in March 2013.1 The… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Dolutegravir has been shown to be non-inferior to an integrase inhibitor and superior to a non-nucleoside reverse… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Dolutegravir (S/GSK1349572), a once-daily, unboosted integrase inhibitor, was recently approved in the United States… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Dolutegravir (S/GSK1349572) is a once-daily HIV integrase inhibitor with potent antiviral activity and a favourable… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND Dolutegravir (GSK1349572), a once-daily HIV integrase inhibitor, has shown potent antiviral response and a favourable… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND In the primary analysis of SPRING-2 at week 48, dolutegravir showed non-inferior efficacy to and similar tolerability… (More)
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Highly Cited
2013
Highly Cited
2013
Particulate ligands, including cholesterol crystals and amyloid fibrils, induce production of interleukin 1β (IL-1β) dependent on… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Dolutegravir (S/GSK1349572) is a new HIV-1 integrase inhibitor that has antiviral activity with once daily, unboosted… (More)
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Highly Cited
2012
Highly Cited
2012
Integrase (IN) strand transfer inhibitors (INSTIs) have been developed to inhibit the ability of HIV-1 integrase to irreversibly… (More)
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Highly Cited
1994
Highly Cited
1994
Rat liver and kidney were investigated for the presence of sigma (sigma) receptor subtypes by radioligand binding with three… (More)
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