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dolastatin 15

Known as: L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))- 
A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the… 
National Institutes of Health

Papers overview

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Review
2015
Review
2015
The use of synthetic anticancer drugs and other methods followed in cancer therapy have several side effects; and ineffective… 
2007
2007
Several anti-cancer agents are derivative from natural products and microorganisms. The dolastatins are natural peptides derived… 
2003
2003
The antimitotic depsipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue. Dolastatin 15… 
Highly Cited
1999
Highly Cited
1999
Review
1999
Review
1999
  • J. Poncet
  • Current pharmaceutical design
  • 1999
  • Corpus ID: 19601237
The dolastatins and some related compounds are antineoplastic pseudopeptides isolated from the sea hare Dolabella auricularia by… 
Highly Cited
1996
Highly Cited
1996
Abstract Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia that have been shown to… 
Highly Cited
1996
Highly Cited
1996
We have assessed the vascular effects of vinblastine and four other tubulin binding agents (dolastatin 10, dolastatin 15… 
Highly Cited
1995
Highly Cited
1995
We have prepared [3H]dolastatin 10 and examined its interactions with tubulin. Binding kinetics appeared to be biphasic, with a… 
Highly Cited
1993
Highly Cited
1993
BACKGROUND Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia. In vitro studies of… 
1992
1992
The effects of two natural peptides, dolastatin 10 and dolastatin 15, on growth and differentiation of hematopoietic cells were…