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dolastatin 15
Known as:
L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))-
A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Depsipeptides
Microtubule Process
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells.
Masanori Sato
,
M. Sagawa
,
T. Nakazato
,
Y. Ikeda
,
M. Kizaki
International Journal of Oncology
2007
Corpus ID: 6651523
Several anti-cancer agents are derivative from natural products and microorganisms. The dolastatins are natural peptides derived…
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2003
2003
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.
Z. Cruz-Monserrate
,
J. T. Mullaney
,
P. Harran
,
G. Pettit
,
E. Hamel
European Journal of Biochemistry
2003
Corpus ID: 6326120
The antimitotic depsipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue. Dolastatin 15…
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2001
2001
Activity of the dolastatin analogue, LU103793, in malignant melanoma.
J. Smyth
,
M. E. Boneterre
,
+4 authors
A. Hanauske
Annals of Oncology
2001
Corpus ID: 27498554
LU103793, a synthetic analogue of dolastatin 15, showed interesting pre-clinical activity in melanoma xenografts. In this phase…
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Highly Cited
1999
Highly Cited
1999
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.
W. R. Gamble
,
N. Durso
,
+6 authors
M. Boyd
Bioorganic & Medicinal Chemistry
1999
Corpus ID: 28912934
Review
1999
Review
1999
The dolastatins, a family of promising antineoplastic agents.
J. Poncet
Current pharmaceutical design
1999
Corpus ID: 19601237
The dolastatins and some related compounds are antineoplastic pseudopeptides isolated from the sea hare Dolabella auricularia by…
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Highly Cited
1996
Highly Cited
1996
Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.
D. Chaplin
,
G. Pettit
,
C. Parkins
,
S. Hill
The British journal of cancer. Supplement
1996
Corpus ID: 40572701
We have assessed the vascular effects of vinblastine and four other tubulin binding agents (dolastatin 10, dolastatin 15…
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Highly Cited
1996
Highly Cited
1996
Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay
G. Aherne
,
A. Hardcastle
,
+5 authors
L. Kelland
Cancer Chemotherapy and Pharmacology
1996
Corpus ID: 6703369
Abstract Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia that have been shown to…
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Highly Cited
1993
Highly Cited
1993
Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15.
M. Beckwith
,
W. Urba
,
D. Longo
Journal of the National Cancer Institute
1993
Corpus ID: 25717121
BACKGROUND Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia. In vitro studies of…
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1993
1993
Effects of dolastatins on human B-lymphocytic leukemia cell lines.
Zhenwei Hu
,
S. Gignac
,
H. Quentmeier
,
G. Pettit
,
H. Drexler
Leukemia research : a Forum for Studies on…
1993
Corpus ID: 41226522
1992
1992
Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells.
K. Steube
,
D. Grunicke
,
T. Pietsch
,
S. Gignac
,
G. Pettit
,
H. Drexler
Leukemia
1992
Corpus ID: 8009901
The effects of two natural peptides, dolastatin 10 and dolastatin 15, on growth and differentiation of hematopoietic cells were…
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