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dolastatin 15

Known as: L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))- 
A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Depsipeptides
Microtubule Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
A flexible asymmetric approach to methyl 5-alkyltetramates and its application in the synthesis of cytotoxic marine natural product belamide A.
By using a methyl tetramate derivative (R)- or (S)-9 as a novel chiral building block, a direct, flexible, and highly… 
2007
2007
A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells.
Several anti-cancer agents are derivative from natural products and microorganisms. The dolastatins are natural peptides derived… 
2003
2003
A Phase II Study of the Dolastatin 15 Analogue LU 103793 in the Treatment of Advanced Non–Small-Cell Lung Cancer
A phase II study of the dolastatin 15 analog LU 103793 was conducted by the North Central Cancer Treatment Group in patients with… 
2001
2001
Activity of the dolastatin analogue, LU103793, in malignant melanoma.
LU103793, a synthetic analogue of dolastatin 15, showed interesting pre-clinical activity in melanoma xenografts. In this phase… 
Highly Cited
1999
Highly Cited
1999
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.
1998
1998
Phase I and pharmacokinetic study of the water-soluble dolastatin 15 analog LU103793 in patients with advanced solid malignancies.
PURPOSE To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetic profile of the… 
1998
1998
Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines.
BACKGROUND The dolastatins are natural peptides which inhibit microtubule assembly and induce apoptosis in a number of malignant… 
1998
1998
Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications.
Dolastatin 15 (1), a potent antineoplastic constituent of the Indian Ocean shell-less mollusk Dolabella auricularia, was utilized… 
1993
1993
Effects of dolastatins on human B-lymphocytic leukemia cell lines.
1991
1991
Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells.
Dolastatins 10 and 15, isolated from the shell-less marine mollusk Dolabella auricularia, are potent antineoplastic agents with… 
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