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dolastatin 15

Known as: L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))- 
A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Several anti-cancer agents are derivative from natural products and microorganisms. The dolastatins are natural peptides derived… Expand
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2003
2003
A phase II study of the dolastatin 15 analog LU 103793 was conducted by the North Central Cancer Treatment Group in patients with… Expand
2003
2003
The antimitotic depsipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue. Dolastatin 15… Expand
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Review
1999
Review
1999
  • J. Poncet
  • Current pharmaceutical design
  • 1999
  • Corpus ID: 19601237
The dolastatins and some related compounds are antineoplastic pseudopeptides isolated from the sea hare Dolabella auricularia by… Expand
Highly Cited
1996
Highly Cited
1996
We have assessed the vascular effects of vinblastine and four other tubulin binding agents (dolastatin 10, dolastatin 15… Expand
Highly Cited
1996
Highly Cited
1996
Abstract Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia that have been shown to… Expand
Highly Cited
1995
Highly Cited
1995
We have prepared [3H]dolastatin 10 and examined its interactions with tubulin. Binding kinetics appeared to be biphasic, with a… Expand
Highly Cited
1993
Highly Cited
1993
BACKGROUND Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia. In vitro studies of… Expand
Highly Cited
1992
Highly Cited
1992
Dolastatin 15, a seven-subunit depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally… Expand
1992
1992
The effects of two natural peptides, dolastatin 10 and dolastatin 15, on growth and differentiation of hematopoietic cells were… Expand