Skip to search formSkip to main contentSkip to account menu

dolastatin 15

Known as: L-Proline, 1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl)-, 1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))- 
A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Depsipeptides
Microtubule Process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Anticancer compounds from cyanobacterium Lyngbya species: a review
The use of synthetic anticancer drugs and other methods followed in cancer therapy have several side effects; and ineffective… 
2007
2007
A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells.
Several anti-cancer agents are derivative from natural products and microorganisms. The dolastatins are natural peptides derived… 
2003
2003
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.
The antimitotic depsipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue. Dolastatin 15… 
Highly Cited
1999
Highly Cited
1999
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges.
Review
1999
Review
1999
The dolastatins, a family of promising antineoplastic agents.
  • J. Poncet
  • Current pharmaceutical design
  • 1999
  • Corpus ID: 19601237
The dolastatins and some related compounds are antineoplastic pseudopeptides isolated from the sea hare Dolabella auricularia by… 
Highly Cited
1996
Highly Cited
1996
Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay
Abstract Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia that have been shown to… 
Highly Cited
1996
Highly Cited
1996
Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.
We have assessed the vascular effects of vinblastine and four other tubulin binding agents (dolastatin 10, dolastatin 15… 
Highly Cited
1995
Highly Cited
1995
Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions.
We have prepared [3H]dolastatin 10 and examined its interactions with tubulin. Binding kinetics appeared to be biphasic, with a… 
Highly Cited
1993
Highly Cited
1993
Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15.
BACKGROUND Dolastatins 10 and 15 are small peptides isolated from the marine sea hare Dolabella auricularia. In vitro studies of… 
1992
1992
Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells.
The effects of two natural peptides, dolastatin 10 and dolastatin 15, on growth and differentiation of hematopoietic cells were… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License