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diphthamide

Known as: 1H-Imidazole-2-propanaminium, alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-, hydroxide, inner salt, 2-(3-carboxyamido-3-(trimethylammonio)propyl)histidine 
 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
To study the role of the diphthamide modification on eukaryotic elongation factor 2 (eEF2), we generated an eEF2 Gly717Arg mutant… Expand
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Highly Cited
2010
Highly Cited
2010
Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationally modified histidine residue called… Expand
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Highly Cited
2008
Highly Cited
2008
The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT The translation elongation factor 2 in eukaryotes (eEF-2) contains a unique posttranslationally modified histidine… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT Diphthamide, a posttranslational modification of translation elongation factor 2 that is conserved in all eukaryotes and… Expand
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Highly Cited
1994
Highly Cited
1994
Protein synthesis elongation factor 2 (EF-2) from eukaryotes contains an unusual modified histidine residue, termed diphthamide… Expand
Highly Cited
1992
Highly Cited
1992
A mutant of Saccharomyces cerevisiae defective in the S-adenosylmethionine (AdoMet)-dependent methyltransferase step of… Expand
Highly Cited
1984
Highly Cited
1984
Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation… Expand
Highly Cited
1981
Highly Cited
1981
Diphtheria toxin inactivates protein synthesis elongation factor 2 by catalyzing the ADP-ribosylation of a novel derivative of… Expand
Highly Cited
1980
Highly Cited
1980
NMR spectral analysis of the novel amino acid, diphthamide, in elongation factor 2 which is ADP-ribosylated by diphtheria toxin… Expand