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diphthamide

Known as: 1H-Imidazole-2-propanaminium, alpha-(aminocarbonyl)-4-(2-amino-2-carboxyethyl)-N,N,N-trimethyl-, hydroxide, inner salt, 2-(3-carboxyamido-3-(trimethylammonio)propyl)histidine 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Histidine
analogs & derivatives

Papers overview

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2008
2008
Diphtheria toxin mutant CRM197 is an inhibitor of protein synthesis that induces cellular toxicity.
2005
2005
Gene Trap Mutagenesis-based Forward Genetic Approach Reveals That the Tumor Suppressor OVCA1 Is a Component of the Biosynthetic Pathway of Diphthamide on Elongation Factor 2*
OVCA1 is a tumor suppressor identified by positional cloning from chromosome 17p13.3, a hot spot for chromosomal aberration in… 
2004
2004
Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae*
The crystal structure of ADP-ribosylated yeast elongation factor 2 in the presence of sordarin and GDP has been determined at 2.6… 
1997
1997
Induction of apoptosis in multidrug-resistant and radiation-resistant acute myeloid leukemia cells by a recombinant fusion toxin directed against the human granulocyte macrophage colony-stimulating…
Multiagent chemotherapy regimens fail to cure more than one-half of the patients with acute myeloid leukemia (AML) because of the… 
1996
1996
A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3.
1988
1988
Expression of diphtheria toxin fragment A and hormone-toxin fusion proteins in toxin-resistant yeast mutants.
Mutants of the eukaryote Saccharomyces cerevisiae, previously selected for resistance to diphtheria toxin, were investigated for… 
1987
1987
Highly frequent single amino acid substitution in mammalian elongation factor 2 (EF-2) results in expression of resistance to EF-2-ADP-ribosylating toxins.
Highly Cited
1984
Highly Cited
1984
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin
Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation… 
1984
1984
ADP‐ribosyltransferase from beef liver which ADP‐ribosylates elongation factor‐2
Highly Cited
1983
Highly Cited
1983
Occurrence of diphthamide in archaebacteria
We examined the nature of the diphtheria toxin fragment A recognition site in the protein synthesis translocating factor present… 
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