dihydroorotate

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1962-2018
0204019622018

Papers overview

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Highly Cited
2011
Highly Cited
2011
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to… (More)
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2011
2011
Drug therapy is the mainstay of antimalarial therapy, yet current drugs are threatened by the development of resistance. In an… (More)
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Highly Cited
2007
Highly Cited
2007
The origin of all mitochondria can be traced to the symbiotic arrangement that resulted in the emergence of eukaryotes in a world… (More)
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2005
2005
Plasmodium falciparum is the causative agent of the most serious and fatal malarial infections, and it has developed resistance… (More)
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2002
2002
The malarial parasite relies on de novo pyrimidine biosynthesis to maintain its pyrimidine pools, and unlike the human host cell… (More)
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2000
2000
BACKGROUND Dihydroorotate dehydrogenase (DHODH) catalyzes the fourth committed step in the de novo biosynthesis of pyrimidines… (More)
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Highly Cited
1996
Highly Cited
1996
The active metabolite of leflunomide. A771726, is a novel immunosuppressive compound that has been shown to be a powerful… (More)
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1995
1995
Leflunomide [HWA 486 or RS-34821, 5-methyl-N-(4-trifluoromethylphenyl)-4-isoxazole carboximide] is an immunosuppressive agent… (More)
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1995
1995
A protein with high affinity (Kd 12 nM) for the immunomodulatory compound A77 1726 has been isolated from mouse spleen and… (More)
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1994
1994
The pyrimidine de novo biosynthesis pathway has been characterized for a number of organisms. The general pathway consists of six… (More)
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