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dihydroorotate

National Institutes of Health

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4 relations

Broader (1)

4,5-dihydroorotic acid
Dihydroorotate/Creatinine:SRto:Pt:Urine:QnDihydroorotate:SCnc:Pt:CSF:QnDihydroorotate:SCnc:Pt:Urine:Qn

Papers overview

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2012
2012
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases.
The de novo pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase is an emerging drug target for the treatment of malaria… 
2009
2009
Investigation of the Influence of CYP1A2 and CYP2C19 Genetic Polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) Pharmacokinetics in Leflunomide-Treated Patients…
Leflunomide is a disease-modifying antirheumatic drug used for the treatment of rheumatoid arthritis (RA). Cytochromes P450… 
1996
1996
Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria
Dihydroorotate dehydrogenase (EC 1.3.3.1 or EC 1.3.99.11) catalyzes the fourth sequential step in the de novo synthesis of… 
1987
1987
A sensitive, nonradiometric assay for dihydroorotic acid dehydrogenase using anion-exchange high-performance liquid chromatography.
Highly Cited
1982
Highly Cited
1982
UMP synthesis in the kinetoplastida.
1982
1982
Pyrimidine metabolism in Giardia lamblia trophozoites.
1981
1981
An overall radioassay for the first three reactions of de novo pyrimidine biosynthesis.
1975
1975
A new membrane iron-sulfur flavoprotein of the mitochondrial electron transfer system. The entrance point of the fatty acyl dehydrogenation pathway?
1974
1974
Effect of uridine on de novo pyrimidine biosynthesis in rat hepatoma cells in culture.
Highly Cited
1971
Highly Cited
1971
The function of menaquinone (vitamin K 2 ) in Escherichia coli K-12.
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