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dictyostatin

 
National Institutes of Health

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2016
2016
Neurodegenerative disorders referred to as tauopathies, which includes Alzheimer’s disease (AD), are characterized by insoluble… Expand
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2016
2016
A combined biochemical, structural, and cell biology characterization of dictyostatin is described, which enables an improved… Expand
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2013
2013
Inclusions comprising the microtubule (MT)-stabilizing protein, tau, are found within neurons in the brains of patients with… Expand
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2008
2008
A protocol based on a combination of NMR experimental data with molecular mechanics calculations and docking procedures has been… Expand
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2008
2008
Compounds that bind to microtubules (MTs) and alter their dynamics are highly sought as a result of the clinical success of… Expand
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2007
2007
Eleutherobin and dictyostatin are antimitotic compounds which exert their cytotoxic activity by a taxol-like mode of action, i.e… Expand
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2007
2007
The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established through total synthesis of… Expand
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2006
2006
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated… Expand
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2005
2005
(-)-Dictyostatin is a sponge-derived, 22-member macrolactone natural product shown to cause cells to accumulate in the G2/M phase… Expand
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2005
2005
[structure: see text] (-)-16-Normethyldictyostatin has been made by total synthesis and is a potent antitumor agent in cells… Expand
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