dictyostatin

Inclusions comprising the microtubule (MT)-stabilizing protein, tau, are found within neurons in the brains of patients with… (More)

A protocol based on a combination of NMR experimental data with molecular mechanics calculations and docking procedures has been… (More)

Compounds that bind to microtubules (MTs) and alter their dynamics are highly sought as a result of the clinical success of… (More)

Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin and a number of other isomers and… (More)

Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the… (More)

A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated… (More)

(-)-Dictyostatin is a sponge-derived, 22-member macrolactone natural product shown to cause cells to accumulate in the G2/M phase… (More)

[structure: see text] (-)-16-Normethyldictyostatin has been made by total synthesis and is a potent antitumor agent in cells… (More)

[reaction: see text] An esterification/ring-closing metathesis approach to dictyostatin and discodermolide is introduced. The… (More)

[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These… (More)