dictyostatin
National Institutes of Health
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A combined biochemical, structural, and cell biology characterization of dictyostatin is described, which enables an improved…
An approach to the validation of linker strategies for polyketide natural products with few or no obvious handles for linker…
Inclusions comprising the microtubule (MT)-stabilizing protein, tau, are found within neurons in the brains of patients with…
In 1994 Petit reported the isolation and anti-cancer activity of the marine sponge-derived macrolide dictyostatin.[1] Wright…
A formal convergent synthesis of dictyostatin from (R)-Roche ester is described. Synthetic highlights include a Ni-catalyzed…
The natural product (−)-dictyostatin is a microtubule-stabilizing agent that potently inhibits the growth of human cancer cells…
Dictyostatin (DCT, 1) is a complex, flexible polyketide macrolide that demonstrates potent microtubule-polymerization activity…
Abstract Structural modification of the dictyostatin macrolide template through adaptation of our total synthesis has led to the…
Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several…
By employing a diverted total synthesis strategy with late-stage intermediates, 10,11-dihydrodictyostatin ( 5) was prepared and…