dictyostatin
National Institutes of Health
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Neurodegenerative disorders referred to as tauopathies, which includes Alzheimer’s disease (AD), are characterized by insoluble…
Inclusions comprising the microtubule (MT)-stabilizing protein, tau, are found within neurons in the brains of patients with…
In 1994 Petit reported the isolation and anti-cancer activity of the marine sponge-derived macrolide dictyostatin.[1] Wright…
The dictyostatins are a promising class of potential anti-cancer drugs because they are powerful microtubule-stabilizing agents…
A protocol based on a combination of NMR experimental data with molecular mechanics calculations and docking procedures has been…
Abstract Eleutherobin and dictyostatin are antimitotic compounds which exert their cytotoxic activity by a taxol-like mode of…
The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established through total synthesis of…
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated…
(-)-Dictyostatin is a sponge-derived, 22-member macrolactone natural product shown to cause cells to accumulate in the G2/M phase…
[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These…