dictyostatin

The dictyostatins are a promising class of potential anti-cancer drugs because they are powerful microtubule-stabilizing agents… Expand

A protocol based on a combination of NMR experimental data with molecular mechanics calculations and docking procedures has been… Expand

Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin and a number of other isomers and… Expand

Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the… Expand

Eleutherobin and dictyostatin are antimitotic compounds which exert their cytotoxic activity by a taxol-like mode of action, i.e… Expand

The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established through total synthesis of… Expand

A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated… Expand

(-)-Dictyostatin is a sponge-derived, 22-member macrolactone natural product shown to cause cells to accumulate in the G2/M phase… Expand

Will the real dictyostatin please stand up? There were five finalists as stereostructures for the potent anticancer agent… Expand

[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These… Expand