dictyostatin
National Institutes of Health
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An approach to the validation of linker strategies for polyketide natural products with few or no obvious handles for linker…
Herein, we report a robust total synthesis of dictyostatin. This polyketide natural product has attracted much attention because…
In 1994 Petit reported the isolation and anti-cancer activity of the marine sponge-derived macrolide dictyostatin.[1] Wright…
A formal convergent synthesis of dictyostatin from (R)-Roche ester is described. Synthetic highlights include a Ni-catalyzed…
Microtubules are key components of cytoskeleton and they play role in maintaining cell structure ,providing platforms for…
The natural product (−)-dictyostatin is a microtubule-stabilizing agent that potently inhibits the growth of human cancer cells…
The dictyostatins are powerful microtubule-stabilizing agents that have shown antiproliferative activity against a variety of…
Abstract Structural modification of the dictyostatin macrolide template through adaptation of our total synthesis has led to the…
Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several…
By employing a diverted total synthesis strategy with late-stage intermediates, 10,11-dihydrodictyostatin ( 5) was prepared and…