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dictyostatin

 
National Institutes of Health

Papers overview

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2010
2010
The dictyostatins are a promising class of potential anti-cancer drugs because they are powerful microtubule-stabilizing agents… Expand
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Highly Cited
2008
Highly Cited
2008
A protocol based on a combination of NMR experimental data with molecular mechanics calculations and docking procedures has been… Expand
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2007
2007
Total syntheses of (-)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin and a number of other isomers and… Expand
2007
2007
Novel analogues of the microtubule-stabilising agent dictyostatin were designed using existing SAR information from the… Expand
2007
2007
Eleutherobin and dictyostatin are antimitotic compounds which exert their cytotoxic activity by a taxol-like mode of action, i.e… Expand
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2007
2007
The structure-activity relationship of the crucial C16 region of (-)-dictyostatin was established through total synthesis of… Expand
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Highly Cited
2006
Highly Cited
2006
A convergent total synthesis of dictyostatin is described. Key features of the synthesis include the use of titanium-mediated… Expand
Highly Cited
2005
Highly Cited
2005
(-)-Dictyostatin is a sponge-derived, 22-member macrolactone natural product shown to cause cells to accumulate in the G2/M phase… Expand
Highly Cited
2004
Highly Cited
2004
Will the real dictyostatin please stand up? There were five finalists as stereostructures for the potent anticancer agent… Expand
Highly Cited
2002
Highly Cited
2002
[structure: see text] Two hybrid analogues of discodermolide and dictyostatin (3, 26) have been designed and synthesized. These… Expand