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diclofurime

Known as: 2,3-dichloro-4-methoxyphenyl 2-furyl ketone (E)-O-(2-(diethylamino)ethyl)oxime 
National Institutes of Health

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2 relations

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ANP 4364

Broader (1)

Oximes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
Pharmacophore modelling of structurally unusual diltiazem mimics at L-type calcium channels
The purpose of this theoretical study was to investigate the molecular features of some structurally unusual calcium antagonists… 
1987
1987
Calcium Antagonist Properties of Diclofurime Isomers. I. Functional Aspects
diclofurime has been shown to be a potent calcium antagonist which resembles verapamil in vitro and in vivo. Trans-diclofurime… 
1987
1987
Electrophysiological effects of diclofurime on rabbit and frog atrial heart muscle
1 The effects of diclofurime on the electrical activity of the rabbit sinus node, rabbit atria and frog atrial fibres were… 
1985
1985
Metabolic pathway by cleavage of a furan ring.
14C-Diclofurime, a new Ca antagonist, was administered orally to dogs and pigs, and metabolites detected in urine and plasma… 
1984
1984
Interactions between a “calcium channel agonist”, Bay K 8644, and calcium antagonists differentiate calcium antagonist subgroups in K+-depolarized smooth muscle
Summary1.The proposal that calcium antagonists have different sites of action has been tested by attempting to reverse their… 
1981
1981
[Diclofurime: a new antihypertensive agent. Effectiveness and kidney tolerance].
Diclofurime is a non-inotropic arterial vasodilator and an antagonist to calcium transport. We studied its antihypertensive… 
1980
1980
[Diclofurime, a new major hypotensive agent. Clinical study in 24 patients (author's transl)].
Diclofurine is a new ketone-oxime derivative with potent peripheral vasodilating properties. Its hypotensive effects were studied… 
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