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deoxycytidine kinase activity

Known as: NTP:deoxycytidine 5'-phosphotransferase activity, Ara-C kinase activity, deoxycytidine-cytidine kinase activity 
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. [EC:2.7.1.74]
National Institutes of Health

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Deoxycytidine Kinase

Papers overview

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2010
2010
Influence of Phosphorylation of THR-3, SER-11, and SER-15 on Deoxycytidine Kinase Activity and Stability
Deoxycytidine kinase (dCK) is a key enzyme in the salvage of deoxyribonucleosides and in the activation of several anticancer and… 
1993
1993
Regulation of deoxycytidine kinase activity and inhibition by DFDC.
1992
1992
Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine.
The activity of deoxycytidine kinase (EC 2.7.1.74), an important pyrimidine salvage enzyme, was elevated 5- to 30-fold in human… 
1989
1989
Dideoxycytidine metabolism in wild type and mutant CEM cells deficient in nucleoside transport or deoxycytidine kinase.
The growth inhibitory effects and metabolism of 2',3'-dideoxycytidine (ddC) were examined in wild type human CEM T lymphoblasts… 
1989
1989
Development of resistance to 1-beta-D-arabinofuranosylcytosine after high-dose treatment in childhood lymphoblastic leukemia: analysis of resistance mechanism in established cell lines.
Cell lines PER-163 and PER-164 are derived from a patient with acute lymphoblastic leukemia who developed resistance to 1-beta-D… 
1987
1987
High degree of resistance to 5-aza-2'-deoxycytidine in L1210 cells in vitro associated with almost complete loss of deoxycytidine kinase activity.
In L1210 mouse leukemic cells the resistance towards 5-aza-2'-deoxycytidine was developed in vitro by stepwise selection in… 
1985
1985
1-beta-D-arabinofuranosylcytosine metabolism and incorporation into DNA as determinants of in vivo murine tumor cell response.
In this study, 1-beta-D-arabinofuranosylcytosine 5'-triphosphate (ara-CTP) formation, retention, and incorporation into DNA were… 
1980
1980
The induction and characterization of mouse lymphoma L5178Y cell lines resistant to 1-beta-d-arabinofuranosylcytosine.
1973
1973
Demonstration of a deoxycytidine kinase activity in extracts of Bacillus megaterium KM.
Extracts of Bacillus megaterium KM have been shown to possess a deoxycytidine kinase activity which functions optimally with… 
1968
1968
Studies on the mode of action of the copper(II)chelate of 2-keto-3-ethoxybutyraldehyde-bis(thiosemicarbazone).
Summary Among 2-keto-3-ethoxybutyraldehyde-bis(thiosemicarbazone) (KTS) and its metal chelates, Cu(II)KTS was selected for… 
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