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deoxycytidine kinase activity

Known as: NTP:deoxycytidine 5'-phosphotransferase activity, Ara-C kinase activity, deoxycytidine-cytidine kinase activity 
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. [EC:2.7.1.74]
National Institutes of Health

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Deoxycytidine Kinase

Papers overview

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2014
2014
New insights into the regulation of deoxycytidine kinase activity via Ser-74 phosphorylation : toward improved activation of anticancer nucleoside analogs
Deoxycytidine kinase (dCK) catalyzes the phosphorylation of deoxycytidine, deoxyadenosine and deoxyguanosine, which constitutes… 
2006
2006
Development of Resistance to l-/?-D-Arabinofuranosylcytosine after Treatment in Childhood Lymphoblastic Leukemia: Analysis of Resistance Mechanism in Established Cell Lines1
Cell lines PER-163 and PER-164 are derived from a patient with acute lymphobias) ic leukemia who developed resistance to 1-0-D… 
2001
2001
Simultaneous treatment with 1-beta-D-arabinofuranosylcytosine and daunorubicin induces cross-resistance to both drugs due to a combination-specific mechanism in HL60 cells.
We have established a human myelogenous leukemia cell line (HL60/AD) that is 10-fold cross-resistant to both 1-beta-D… 
1986
1986
Arabinosyl-5-azacytosine: mechanisms of native and acquired resistance.
Factors influencing the activity of the nucleoside analogue arabinosyl-5-azacytosine (ara-AC) were studied in P388 murine… 
1986
1986
Thymidine kinase with altered substrate specificity of acyclovir resistant varicella-zoster virus.
The acyclovir resistant mutant of varicella-zoster virus ACV-R (A 8) induced the same level of thymidine kinase activity in… 
1984
1984
Establishment of human KB cells resistant to 1-beta-D-arabinofuranosylcytosine, and mechanisms of cellular resistance in isolated clones.
A subline of human KB cells that was resistant to 1-beta-D-arabinofuranosylcytosine (ara-C) was established by continuous… 
Highly Cited
1981
Highly Cited
1981
Identification of the mechanism of activation of 9-beta-D-arabinofuranosyladenine in human lymphoid cells using mutants deficient in nucleoside kinases.
The biochemical basis of cellular resistance to 9-beta-D-arabinofuranosyladenine (ara-A) and its natural purine derivative… 
1977
1977
Cell-free synthesis of herpes simplex virus-coded pyrimidine deoxyribonucleoside kinase enzyme
The incubation of a cell-free protein-synthesizing system prepared from rabbit reticulocytes with cytoplasmic RNA from herpes… 
1973
1973
Demonstration of a deoxycytidine kinase activity in extracts of Bacillus megaterium KM.
Extracts of Bacillus megaterium KM have been shown to possess a deoxycytidine kinase activity which functions optimally with… 
1968
1968
Studies on the mode of action of the copper(II)chelate of 2-keto-3-ethoxybutyraldehyde-bis(thiosemicarbazone).
Summary Among 2-keto-3-ethoxybutyraldehyde-bis(thiosemicarbazone) (KTS) and its metal chelates, Cu(II)KTS was selected for… 
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