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deoxycytidine kinase activity

Known as: NTP:deoxycytidine 5'-phosphotransferase activity, Ara-C kinase activity, deoxycytidine-cytidine kinase activity 
Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP. [EC:2.7.1.74]
National Institutes of Health

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Related topics

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Deoxycytidine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Cladribine inhibits cytokine secretion by T cells independently of deoxycytidine kinase activity
Cladribine (2-chloro-2'-deoxyadenosine) is a purine nucleoside analogue (PNA) which causes targeted and sustained reduction of… 
2005
2005
Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients
Objective:To evaluate whether an inter-individual variability in the activity of thymidine kinase (TK) and deoxycytidine kinase… 
2000
2000
Effect of phosphorylation on deoxycytidine kinase activity.
In contrast to deoxycytidine kinase from leukemic blasts7, the recombinant dCK is a poor substrate for protein kinase C. Protein… 
Highly Cited
1999
Highly Cited
1999
Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity.
Deoxycytidine kinase (dCK), one of the rate-limiting enzymes in the intracellular metabolism of many antileukaemic drugs, was… 
1993
1993
Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate-enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2'-deoxycytidine.
Deoxycytidine kinase activity (dCk) was monitored in cell lines from a rat acute myeloid leukemia model of acquired resistance to… 
1993
1993
Regulation of deoxycytidine kinase activity and inhibition by DFDC.
(1) Deoxycytidine kinase activity increased in a transformation- and progression-linked fashion in rat hepatomas of different… 
1992
1992
Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine.
The activity of deoxycytidine kinase (EC 2.7.1.74), an important pyrimidine salvage enzyme, was elevated 5- to 30-fold in human… 
1989
1989
Dideoxycytidine metabolism in wild type and mutant CEM cells deficient in nucleoside transport or deoxycytidine kinase.
  • B. Ullman
  • Advances in experimental medicine and biology
  • 1989
  • Corpus ID: 43261136
The growth inhibitory effects and metabolism of 2',3'-dideoxycytidine (ddC) were examined in wild type human CEM T lymphoblasts… 
Highly Cited
1988
Highly Cited
1988
Genetic analysis of 2',3'-dideoxycytidine incorporation into cultured human T lymphoblasts.
In order to analyze the cellular determinants that mediate the action of 2',3'-dideoxycytidine, the growth inhibitory and… 
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Highly Cited
1974
Highly Cited
1974
Induction of both thymidine and deoxycytidine kinase activity by herpes viruses.
Summary Genetical and biochemical evidence indicates that herpes simplex virus (types 1 and 2) specifies a unique kinase activity… 
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