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dendritic spine morphogenesis

The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite… Expand
National Institutes of Health

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Broader (2)

dendrite morphogenesisdendritic spine development

Papers overview

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Highly Cited
2010
Highly Cited
2010
Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis
The high resolution structure of the cytoskeleton in dendritic spines and their precursors, dendritic filopodia, was… Expand
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Highly Cited
2009
Highly Cited
2009
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
The microRNA pathway has been implicated in the regulation of synaptic protein synthesis and ultimately in dendritic spine… Expand
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Highly Cited
2006
Highly Cited
2006
The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis
PAR-3 (partitioning-defective gene 3) is essential for cell polarization in many contexts, including axon specification. However… Expand
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Highly Cited
2005
Highly Cited
2005
Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases.
The small GTPases Rac1 and Cdc42 are key regulators of the morphogenesis of actin-rich dendritic spines in neurons. However… Expand
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Highly Cited
2003
Highly Cited
2003
Rapid Induction of Dendritic Spine Morphogenesis by trans-Synaptic EphrinB-EphB Receptor Activation of the Rho-GEF Kalirin
The morphogenesis of dendritic spines, the major sites of excitatory synaptic transmission in the brain, is important in synaptic… Expand
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Highly Cited
2003
Highly Cited
2003
Inhibition of dendritic spine morphogenesis and synaptic transmission by activity-inducible protein Homer1a.
The postsynaptic density (PSD) proteins Shank and Homer cooperate to induce the maturation and enlargement of dendritic spines… Expand
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Highly Cited
2003
Highly Cited
2003
Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis.
Dendritic spines have two major structural elements: postsynaptic densities (PSDs) and actin cytoskeletons. PSD proteins are… Expand
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Highly Cited
2003
Highly Cited
2003
Activity-dependent redistribution and essential role of cortactin in dendritic spine morphogenesis.
The number and shape of dendritic spines are influenced by activity and regulated by molecules that organize the actin… Expand
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Highly Cited
2002
Highly Cited
2002
Cadherin Regulates Dendritic Spine Morphogenesis
Synaptic remodeling has been postulated as a mechanism underlying synaptic plasticity, and cadherin adhesion molecules are… Expand
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Highly Cited
2001
Highly Cited
2001
EphB/Syndecan-2 Signaling in Dendritic Spine Morphogenesis
We previously reported that the cell surface proteoglycan syndecan-2 can induce dendritic spine formation in hippocampal neurons… Expand
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