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A synaptic model of memory: long-term potentiation in the hippocampus
The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression
It is shown that long-term depression can be readily induced in adult cortex by the activation of NMDA receptors (NMDARs), after inhibition of glutamate uptake, and there is no need to activate synaptic N MDARs to induce this LTD, suggesting that LTD is triggered primarily by extrasynapticNMDA receptors.
Receptor trafficking and synaptic plasticity
Insight into how these receptors are rapidly moved into and out of synaptic membranes has profound implications for the understanding of the mechanisms of long-term potentiation and long- term depression.
Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.
Results indicate that the synaptic receptor in the Schaffer collateral‐commissural pathway may be of the kainate or quisqualate type and although NMA receptors do not appear to be involved in normal synaptic transmission in this pathway they may play a role in synaptic plasticity.
LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Long-term depression in the CNS
- G. Collingridge, S. Peineau, J. Howland, Y. T. Wang
- Biology, PsychologyNature Reviews Neuroscience
- 1 July 2010
Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response.
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
It is demonstrated that long-term potentiation in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs, which are physiologically expressed at CA1Pyramidal cell synapses during LTP, and may be required for LTP consolidation.
Modulation of AMPA receptor unitary conductance by synaptic activity
It is shown that elementary channel properties can be rapidly modified by synaptic activity and provides an insight into one molecular mechanism by which glutamatergic synapses can alter their strength.
Kainate receptors: Pharmacology, function and therapeutic potential