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A synaptic model of memory: long-term potentiation in the hippocampus
Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates. The best understood… Expand
Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression
- Peter V. Massey, B. E. Johnson, +5 authors Z. Bashir
- Biology, Medicine
- The Journal of Neuroscience
- 8 September 2004
It is widely believed that long-term depression (LTD) and its counterpart, long-term potentiation (LTP), involve mechanisms that are crucial for learning and memory. However, LTD is difficult to… Expand
Receptor trafficking and synaptic plasticity
Long-term potentiation and long-term depression are processes that have been widely studied to understand the molecular basis of information storage in the brain. Glutamate receptors are required for… Expand
Long-term depression in the CNS
- G. Collingridge, S. Peineau, J. Howland, Y. Wang
- Biology, Medicine
- Nature Reviews Neuroscience
- 1 July 2010
Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several… Expand
Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus.
1. The effects of excitatory amino acids and some antagonists applied by ionophoresis to stratum radiatum in the CA1 region of rat hippocampal slices were examined on the locally recorded field… Expand
LTP Inhibits LTD in the Hippocampus via Regulation of GSK3β
Glycogen synthase kinase-3 (GSK3) has been implicated in major neurological disorders, but its role in normal neuronal function is largely unknown. Here we show that GSK3beta mediates an interaction… Expand
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Postnatal glutamatergic principal neuron synapses are typically presumed to express only calcium-impermeable (CI), GluR2-containing AMPARs under physiological conditions. Here, however, we… Expand
Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus.
1. Intracellular recording techniques were used to characterize monosynaptic inhibitory postsynaptic potentials (IPSPs) and currents (IPSCs) in rat hippocampal slices and to study the mechanism of… Expand
Modulation of AMPA receptor unitary conductance by synaptic activity
Activity-dependent alteration in synaptic strength is a fundamental property of the vertebrate central nervous system and is thought to underlie learning and memory. The most extensively studied… Expand
Excitatory amino acid receptors in the vertebrate central nervous system.
Mixed esters of dibasic unsaturated acids, glycols and glycidyl esters, when formulated with aminoplast resins, form coating compositions which require little or no organic liquid carrier. These… Expand