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Guidelines for the use and interpretation of assays for monitoring autophagy
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting tyrosine phosphorylation into theExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.
The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensivelyExpand
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Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family ofExpand
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Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
THE neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations1,2. Although the long-term effects of neurotrophins on neuronalExpand
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LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.
The ciliary neurotrophic factor (CNTF) receptor complex is shown here to include the CNTF binding protein (CNTFR alpha) as well as the components of the leukemia inhibitory factor (LIF) receptor,Expand
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Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophinExpand
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Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4
NERVE growth factor and other neurotrophins signal to neurons through the Trk family of receptor tyrosine kinases1–6. TrkB is relatively promiscuous in vitro, acting as a receptor for brain-derivedExpand
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Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
The development of dendritic spines is thought to be crucial for synaptic plasticity. Dendritic spines are retracted upon Eph receptor A4 (EphA4) activation, but the mechanisms that control thisExpand
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