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denagliptin

Known as: 4-fluoro-1-(4-fluoro-(4-fluorophenyl)phenylalanyl)-2-pyrrolidinecarbonitrile 
A potent, selective, orally bioavailable, fluoropyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
National Institutes of Health

Papers overview

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2014
2014
The present invention relates to a solid state form denagliptin song and its preparation and uses, particularly, to a new method… Expand
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2014
2014
The present invention relates to a new method for preparing high purity song denagliptin of succinic acid. According to the… Expand
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2014
2014
One kind of DPP-IV inhibitors curved crystal and denagliptin hemisuccinate, and hemisuccinate song denagliptin crystal… Expand
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2014
2014
本发明公开了一种氢溴酸替格列汀的合成方法,具体包括以下步骤,(1)1‑[4‑(3‑甲基‑1‑苯基‑1H‑吡唑‑5‑基)哌嗪(式Ⅰ)和3‑[(2S)‑1‑(1,1‑二甲基乙酰基羰基)‑4‑氧代吡咯烷‑2… Expand
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Review
2013
Review
2013
Type 2 diabetes is metabolic disorder characterized by insulin resistance at peripheral target tissues and pancreatic β-cell… Expand
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2010
2010
Stress testing or forced degradation studies of denagliptin (1) tosylate in solution and solid-state, its blends with excipients… Expand
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