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denagliptin

Known as: 4-fluoro-1-(4-fluoro-(4-fluorophenyl)phenylalanyl)-2-pyrrolidinecarbonitrile 
A potent, selective, orally bioavailable, fluoropyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

PhenylalaninePyrrolidines
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
One suitable high purity industrial succinate production method curved denagliptin
The present invention relates to a new method for preparing high purity song denagliptin of succinic acid. According to the… 
2014
2014
One kind of hydrobromic acid synthesis method for denagliptin
本发明公开了一种氢溴酸替格列汀的合成方法，具体包括以下步骤，(1)1‑[4‑(3‑甲基‑1‑苯基‑1H‑吡唑‑5‑基)哌嗪(式Ⅰ)和3‑[(2S)‑1‑(1,1‑二甲基乙酰基羰基)‑4‑氧代吡咯烷‑2… 
2014
2014
Qu and denagliptin solid form preparation and use
The present invention relates to a solid state form denagliptin song and its preparation and uses, particularly, to a new method… 
2014
2014
Qu denagliptin hemisuccinate crystal and preparation method and pharmaceutical compositions
One kind of DPP-IV inhibitors curved crystal and denagliptin hemisuccinate, and hemisuccinate song denagliptin crystal… 
Review
2013
Review
2013
Serendipity of fluorine in discovery and development of antidiabetic agents: A bottleneck Systemic Review
Type 2 diabetes is metabolic disorder characterized by insulin resistance at peripheral target tissues and pancreatic β-cell… 
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