Skip to search formSkip to main contentSkip to account menu

deguelin

Known as: (7aS-cis)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Rotenone
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Deguelin Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells through Regulating the Expression of Galectin-1
Lung cancer is the leading cause of cancer mortality around the world. Despite advances in the targeted therapy, patients with… 
2015
2015
Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion
Deguelin is a nature-derived chemopreventive drug. Endothelial progenitor cells (EPCs) are bone-marrow (BM)-derived key… 
Highly Cited
2012
Highly Cited
2012
Deguelin, an Akt Inhibitor, Down-Regulates NF-κB Signaling and Induces Apoptosis in Colon Cancer Cells and Inhibits Tumor Growth in Mice
BackgroundDeguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor effect on several… 
2011
2011
Activation of STAT1 is required for interferon-alpha-mediated cell death.
Highly Cited
2008
Highly Cited
2008
A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
The natural compound deguelin has promising preventive and therapeutic activity against diverse cancers by directly binding to… 
2007
2007
Deguelin inhibits expression of IκBα protein and induces apoptosis of B-CLL cells in vitro
We investigated if deguelin, a naturally occurring rotenoid, was able to inhibit nuclear factor kappa B (NF-κB)-binding protein… 
2006
2006
Deguelin inhibits expression of IκBα protein in Raji and U937 cells
AbstractAim:To determine whether deguelin can regulate the expression of nuclear factor kappa B (NF-κB) binding protein (IκBα) in… 
Highly Cited
2005
Highly Cited
2005
Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway
Activation of the phosphoinositide 3 kinase (PI3K)/Akt signalling pathway has been linked with resistance to chemotherapeutic… 
2005
2005
Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro
AbstractAim:To investigate the anticancer effects and the molecular mechanisms of deguelin on human U937 leukemia cells, and to… 
2003
2003
Deguelin suppresses the formation of carcinogen‐induced aberrant crypt foci in the colon of CF‐1 mice
Deguelin [(7aS,BaS)‐13,13a‐dihydro‐9,10‐dimethoxy‐3,3‐dimethyl‐3H‐Bis[1]benzopyrano[3,4‐b:6′,5′‐e]pyran‐7(7aH)‐one], a naturally… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)