deguelin

Known as: (7aS-cis)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one 
 
National Institutes of Health

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2 relations

Broader (1)

Rotenone
analogs & derivatives

Papers overview

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2008
2008
Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha.
Hypoxia-inducible factor 1 (HIF-1) plays an essential role in tumor angiogenesis and growth by regulating the transcription of… (More)
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2008
2008
Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis.
Deguelin is a rotenoid isolated from several plant species, which has been reported to have chemopreventive effects in skin… (More)
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2008
2008
Deguelin inhibits retinal neovascularization by down-regulation of HIF-1α in oxygen-induced retinopathy
Retinal neovascularization is the most common cause of blindness; Retinopathy of pre-maturity (ROP) for children and diabetic… (More)
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2007
2007
Structural basis for depletion of heat shock protein 90 client proteins by deguelin.
BACKGROUND The molecular chaperone heat shock protein 90 (Hsp90) participates in preserving the expression and activity of… (More)
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2007
2007
The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway.
Several natural compounds, especially plant products and dietary constituents, are able to exhibit 'angiopreventive' (anti… (More)
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Highly Cited
2005
Highly Cited
2005
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Tobacco carcinogens induce Akt activation and lung carcinogenesis. We previously demonstrated that deguelin, a natural plant… (More)
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2004
2004
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells.
The increased expression of cyclooxygenase (COX)-2 significantly enhances carcinogenesis and inflammatory reactions, and its… (More)
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Highly Cited
2003
Highly Cited
2003
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
BACKGROUND Because lung cancer is the leading cause of cancer-related death, new approaches for preventing and controlling the… (More)
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2001
2001
Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats
Purpose: To study the pharmacokinetics of deguelin, a naturally occurring potential cancer chemopreventive agent, in rats… (More)
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Highly Cited
1997
Highly Cited
1997
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12… (More)
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