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db/db Mouse
Known as:
db/db
The diabetic mutant mouse was derived from a spontaneous mutation in a C57BL/K progenitor mouse at the Jackson Laboratory in 1966. The db/db mouse is…
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National Institutes of Health
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Highly Cited
2011
Highly Cited
2011
Dysregulation of the unfolded protein response in db/db mice with diet‐induced steatohepatitis
M. Rinella
,
M. Siddiqui
,
Konstantina Gardikiotes
,
J. Gottstein
,
M. Elias
,
Richard M. Green
Hepatology
2011
Corpus ID: 205880320
In humans with nonalcoholic fatty liver, diabetes is associated with more advanced disease. We have previously shown that…
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Highly Cited
2007
Highly Cited
2007
Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice.
M. Barati
,
M. Merchant
,
Angela B Kain
,
A. Jevans
,
K. Mcleish
,
J. Klein
AJP - Renal Physiology
2007
Corpus ID: 18361445
To attain a profile of protein expression during diabetes, we applied proteomic analysis to glomeruli of 160-day-old db/db…
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Highly Cited
2005
Highly Cited
2005
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated…
P. Devasthale
,
Sean Chen
,
+28 authors
P. Cheng
Journal of Medicinal Chemistry
2005
Corpus ID: 39121983
Muraglitazar/BMS-298585 (2) has been identified as a non-thiazolidinedione PPAR alpha/gamma dual agonist that shows potent…
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Highly Cited
2005
Highly Cited
2005
Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
F. Carneiro
,
F. Carneiro
,
+8 authors
R. Webb
Journal of Sexual Medicine
2005
Corpus ID: 25209703
INTRODUCTION Erectile dysfunction (ED) in diabetes is associated with autonomic neuropathy and endothelial dysfunction. Whereas…
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Highly Cited
2004
Highly Cited
2004
Rosiglitazone Induction of Insig-1 in White Adipose Tissue Reveals a Novel Interplay of Peroxisome Proliferator-activated Receptor γ and Sterol Regulatory Element-binding Protein in the Regulation of…
Heidi R. Kast-Woelbern
,
S. Dana
,
+7 authors
M. D. Leibowitz
Journal of Biological Chemistry
2004
Corpus ID: 42598885
Insulin-induced gene 1 (INSIG-1) is a key regulator in the processing of the sterol regulatory element-binding proteins (SREBPs…
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Highly Cited
2003
Highly Cited
2003
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice
M. Sleeman
,
K. Garcia
,
+5 authors
Stanley J. Wiegand
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 36174243
Obesity plays a central role in the development of insulin resistance and type 2 diabetes. We therefore examined the effects of a…
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Highly Cited
2002
Highly Cited
2002
A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while…
G. Etgen
,
B. A. Oldham
,
+18 authors
R. Kauffman
Diabetes
2002
Corpus ID: 29436592
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-alpha/gamma agonist, LY465608, was designed…
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Highly Cited
1999
Highly Cited
1999
Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor.
Christian Bjørbæk
,
J. Elmquist
,
+4 authors
J. Flier
Endocrinology
1999
Corpus ID: 207072926
Ciliary neurotrophic factor (CNTF) is a neurocytokine expressed in glial cells that acts on brain cells to promote gene…
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Highly Cited
1996
Highly Cited
1996
Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice.
Richard B. Lynn
,
G. Cao
,
Robert V. Considine
,
Thomas M. Hyde
,
Jose F. Caro
Biochemical and Biophysical Research…
1996
Corpus ID: 3250204
The obese gene product, leptin, is synthesized in adipose tissue and is a circulating factor regulating body weight. To identify…
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Highly Cited
1995
Highly Cited
1995
Effect of nerve growth factor on peptide neurons in dorsal root ganglia after taxol or cisplatin treatment and in diabetic (db/db) mice
Yorn Schmidt
,
J. Unger
,
I. Bartke
,
R. Reiter
Experimental Neurology
1995
Corpus ID: 43383778
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