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db/db Mouse

Known as: db/db 
The diabetic mutant mouse was derived from a spontaneous mutation in a C57BL/K progenitor mouse at the Jackson Laboratory in 1966. The db/db mouse is… 
National Institutes of Health

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Clinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2011
Highly Cited
2011
Dysregulation of the unfolded protein response in db/db mice with diet‐induced steatohepatitis
In humans with nonalcoholic fatty liver, diabetes is associated with more advanced disease. We have previously shown that… 
Highly Cited
2007
Highly Cited
2007
Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice.
To attain a profile of protein expression during diabetes, we applied proteomic analysis to glomeruli of 160-day-old db/db… 
Highly Cited
2005
Highly Cited
2005
Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated…
Muraglitazar/BMS-298585 (2) has been identified as a non-thiazolidinedione PPAR alpha/gamma dual agonist that shows potent… 
Highly Cited
2005
Highly Cited
2005
Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.
INTRODUCTION Erectile dysfunction (ED) in diabetes is associated with autonomic neuropathy and endothelial dysfunction. Whereas… 
Highly Cited
2004
Highly Cited
2004
Rosiglitazone Induction of Insig-1 in White Adipose Tissue Reveals a Novel Interplay of Peroxisome Proliferator-activated Receptor γ and Sterol Regulatory Element-binding Protein in the Regulation of…
Insulin-induced gene 1 (INSIG-1) is a key regulator in the processing of the sterol regulatory element-binding proteins (SREBPs… 
Highly Cited
2003
Highly Cited
2003
Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice
Obesity plays a central role in the development of insulin resistance and type 2 diabetes. We therefore examined the effects of a… 
Highly Cited
2002
Highly Cited
2002
A tailored therapy for the metabolic syndrome: the dual peroxisome proliferator-activated receptor-alpha/gamma agonist LY465608 ameliorates insulin resistance and diabetic hyperglycemia while…
A novel nonthiazolidinedione dual peroxisome proliferator- activated receptor (PPAR)-alpha/gamma agonist, LY465608, was designed… 
Highly Cited
1999
Highly Cited
1999
Activation of SOCS-3 Messenger Ribonucleic Acid in the Hypothalamus by Ciliary Neurotrophic Factor.
Ciliary neurotrophic factor (CNTF) is a neurocytokine expressed in glial cells that acts on brain cells to promote gene… 
Highly Cited
1996
Highly Cited
1996
Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice.
The obese gene product, leptin, is synthesized in adipose tissue and is a circulating factor regulating body weight. To identify… 
Highly Cited
1995
Highly Cited
1995
Effect of nerve growth factor on peptide neurons in dorsal root ganglia after taxol or cisplatin treatment and in diabetic (db/db) mice
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