db/db Mouse

Known as: db/db 
The diabetic mutant mouse was derived from a spontaneous mutation in a C57BL/K progenitor mouse at the Jackson Laboratory in 1966. The db/db mouse is… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Diabetic nephropathy is a leading cause of end-stage renal failure and is a growing concern given the increasing incidence of… (More)
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Highly Cited
2004
Highly Cited
2004
Although it is known that insulin-dependent (type 1) diabetes results in depressed contractile performance associated with… (More)
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Highly Cited
2003
Highly Cited
2003
Glucose and palmitate metabolism and contractile function were measured with ex vivo perfused working hearts from control (db… (More)
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Highly Cited
2002
Highly Cited
2002
Advanced glycation end products (AGEs), known promoters of diabetic complications, form abundantly in heated foods and are… (More)
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Highly Cited
2002
Highly Cited
2002
Control db/+ and diabetic db/db mice at 6 and 12 wk of age were subjected to echocardiography to determine whether contractile… (More)
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Highly Cited
2001
Highly Cited
2001
Diabetic hyperglycemia increases brain damage after cerebral ischemia in animals and humans, although the underlying mechanisms… (More)
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Highly Cited
2000
Highly Cited
2000
Emerging evidence suggests that transforming growth factor-beta (TGF-beta) is an important mediator of diabetic nephropathy. We… (More)
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Highly Cited
2000
Highly Cited
2000
Contractile function and substrate metabolism were characterized in perfused hearts from genetically diabetic C57BL/KsJ-lepr(db… (More)
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Highly Cited
1996
Highly Cited
1996
OB-R is a high affinity receptor for leptin, an important circulating signal for the regulation of body weight. We identified an… (More)
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Highly Cited
1996
Highly Cited
1996
Leptin, a hormone secreted by adipocytes, regulates the size of the adipose tissue mass through effects on satiety and energy… (More)
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