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Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.

The data suggest that the convulsions as well as the tolerance induced by BW373U86 were initiated through delta opioid receptors.
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A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86.

The data suggest that BW373U86 is a potent and selective nonpeptidic delta agonist, and it elicits distinct in vivo pharmacological activities.
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Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.

DNA topoisomersase II from Drosophila was phosphorylated effectively by protein kinase C and resulted in appreciable activation of the topoisomerase, suggesting that it may represent a possible target for the regulation of nuclear events by protein Kinase C.
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Potent morphiceptin analogs: structure activity relationships and morphine-like activities.

The IC50 values of morphiceptin and its analogs for mu receptor binding were correlated to the ED50 values in the guinea-pig ileum assay, suggesting that the ileu effects were mediated by mu receptor interactions.
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Behavioral effects of the systemically active delta opioid agonist BW373U86 in rhesus monkeys.

Under the conditions evaluated in the present study, the delta receptors to which BW373U86 binds do not appear to mediate antinociceptive, respiratory depressant or reinforcing effects in monkeys.
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A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration.

It is indicated that BW373U86 has a delta agonist profile in the squirrel monkey; however, its antinociceptive effects in the shock titration procedure may be due to its toxic effects.
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Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.

Results support the contention that there are multiple opiate receptors with differing characteristics.
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Specific nonopiate receptors for beta-endorphin.

Iodinated beta H-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes, which suggests the existence of a specific, non-opiate binding site (receptor) for beta- endorphin.
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Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception.

It is proposed that in this experimental respiration model, the delta antagonists naltrindole and H-Tyr-Tic(psi)[CH2NH]Phe- Phe-OH behave like delta agonists with low but sufficient intrinsic activities to reverse alfentanil-induced hypercapnia in rats.
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Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.

Results from the substitutions experiments suggested that a component of the BW373U86 discriminative stimulus was mediated through mu opioid receptors, but the fact that naltrindole was 1000-fold more potent and naltrexone was 30-fold less potent in antagonizing BW 373U86 than morphine indicated that the discriminatives effects of BW373 U86 were also mediated through delta opioid receptors.
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