Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.
- S. Comer, E. M. Hoenicke, J. Woods
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 1993
The data suggest that the convulsions as well as the tolerance induced by BW373U86 were initiated through delta opioid receptors.
A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86.
- K. Chang, G. Rigdon, J. L. Howard, R. Mcnutt
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 1993
The data suggest that BW373U86 is a potent and selective nonpeptidic delta agonist, and it elicits distinct in vivo pharmacological activities.
Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.
- N. Sahyoun, M. Wolf, P. Cuatrecasas
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 March 1986
DNA topoisomersase II from Drosophila was phosphorylated effectively by protein kinase C and resulted in appreciable activation of the topoisomerase, suggesting that it may represent a possible target for the regulation of nuclear events by protein Kinase C.
Potent morphiceptin analogs: structure activity relationships and morphine-like activities.
- K. Chang, E. Wei, A. Killian, J. K. Chang
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 November 1983
The IC50 values of morphiceptin and its analogs for mu receptor binding were correlated to the ED50 values in the guinea-pig ileum assay, suggesting that the ileu effects were mediated by mu receptor interactions.
Behavioral effects of the systemically active delta opioid agonist BW373U86 in rhesus monkeys.
- S. Negus, E. Butelman, K. Chang, B. Decosta, G. Winger, J. Woods
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 September 1994
Under the conditions evaluated in the present study, the delta receptors to which BW373U86 binds do not appear to mediate antinociceptive, respiratory depressant or reinforcing effects in monkeys.
A novel delta opioid agonist, BW373U86, in squirrel monkeys responding under a schedule of shock titration.
- L. Dykstra, G. Schoenbaum, J. Yarbrough, R. Mcnutt, K. Chang
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 November 1993
It is indicated that BW373U86 has a delta agonist profile in the squirrel monkey; however, its antinociceptive effects in the shock titration procedure may be due to its toxic effects.
Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.
- K. Chang, B. Cooper, E. Hazum, P. Cuatrecasas
- Biology, ChemistryMolecular Pharmacology
- 1 July 1979
Results support the contention that there are multiple opiate receptors with differing characteristics.
Specific nonopiate receptors for beta-endorphin.
- E. Hazum, K. Chang, P. Cuatrecasas
- Biology, MedicineScience
- 7 September 1979
Iodinated beta H-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes, which suggests the existence of a specific, non-opiate binding site (receptor) for beta- endorphin.
Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception.
- Y. F. Su, R. Mcnutt, K. Chang
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 December 1998
It is proposed that in this experimental respiration model, the delta antagonists naltrindole and H-Tyr-Tic(psi)[CH2NH]Phe- Phe-OH behave like delta agonists with low but sufficient intrinsic activities to reverse alfentanil-induced hypercapnia in rats.
Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
- S. Comer, R. Mcnutt, K. Chang, B. de Costa, H. Mosberg, J. Woods
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 November 1993
Results from the substitutions experiments suggested that a component of the BW373U86 discriminative stimulus was mediated through mu opioid receptors, but the fact that naltrindole was 1000-fold more potent and naltrexone was 30-fold less potent in antagonizing BW 373U86 than morphine indicated that the discriminatives effects of BW373 U86 were also mediated through delta opioid receptors.
...
...