K. Chang

Publications136
h-index50
Citations9,292
Highly Influential Citations120
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Convulsive effects of systemic administration of the delta opioid agonist BW373U86 in mice.
TLDR
The data suggest that the convulsions as well as the tolerance induced by BW373U86 were initiated through delta opioid receptors. Expand
Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells.
TLDR
DNA topoisomersase II from Drosophila was phosphorylated effectively by protein kinase C and resulted in appreciable activation of the topoisomerase, suggesting that it may represent a possible target for the regulation of nuclear events by protein Kinase C. Expand
Localization of enkephalin‐like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus
TLDR
Cells containing enkephalin‐like immunoreacactivity were found within the somata of three types of hippocampal neurons: granule cells of the dentate gyrus, occasional pyramidal shaped cells of field CA1 stratum pyramidale, and varied scattered interneurons. Expand
Immunohistochemical localization of enkephalin in rat brain and spinal cord
TLDR
The results of the histochemical staining show that certain structures which positively stain for enkephalin closely correspond to the distribution of opiate receptors in the brain and thus support the concept that the endogenous opiate peptides are involved in the perception of pain and analgesia. Expand
A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86.
TLDR
The data suggest that BW373U86 is a potent and selective nonpeptidic delta agonist, and it elicits distinct in vivo pharmacological activities. Expand
Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.
TLDR
Results support the contention that there are multiple opiate receptors with differing characteristics. Expand
Specific nonopiate receptors for beta-endorphin.
TLDR
Iodinated beta H-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes, which suggests the existence of a specific, non-opiate binding site (receptor) for beta- endorphin. Expand
The stimulatory effect of opioids on mitogen-activated protein kinase in Chinese hamster ovary cells transfected to express mu-opioid receptors.
  • L. Li, K. Chang
  • Biology, Medicine
  • Molecular pharmacology
  • 1 September 1996
TLDR
The mitogen-activated protein (MAP) kinase of Chinese hamster ovary cells transfected to express mu-opioid receptors was markedly activated by mu agonists, and opioid-induced activation of MAP kinase activity may have a role in the long term effects of opioids. Expand
Discriminative stimulus effects of BW373U86: a nonpeptide ligand with selectivity for delta opioid receptors.
TLDR
Results from the substitutions experiments suggested that a component of the BW373U86 discriminative stimulus was mediated through mu opioid receptors, but the fact that naltrindole was 1000-fold more potent and naltrexone was 30-fold less potent in antagonizing BW 373U86 than morphine indicated that the discriminatives effects of BW373 U86 were also mediated through delta opioid receptors. Expand
Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines.
TLDR
Results indicate that enkephalins and other low molecular weight opiate-like materials are stored in and secreted from the chromaffin vesicles with catecholamines in the adrenal glands, and suggest that enkphalins may exert important neuroendocrine functions outside the central nervous system. Expand
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