daratumumab

Known as: Anti-CD38 Monoclonal Antibody 
A fully human monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. The binding of anti… (More)
National Institutes of Health

Papers overview

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2017
2017
The majority of patients with immunoglobulin light chain amyloidosis (AL) fail to achieve a complete response (CR) to standard… (More)
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Highly Cited
2016
Highly Cited
2016
BACKGROUND Daratumumab showed promising efficacy alone and with lenalidomide and dexamethasone in a phase 1-2 study involving… (More)
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Highly Cited
2016
Highly Cited
2016
BACKGROUND Daratumumab, a human IgGκ monoclonal antibody that targets CD38, induces direct and indirect antimyeloma activity and… (More)
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Highly Cited
2016
Highly Cited
2016
BACKGROUND New treatment options are needed for patients with multiple myeloma that is refractory to proteasome inhibitors and… (More)
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Highly Cited
2016
Highly Cited
2016
Daratumumab targets CD38-expressing myeloma cells through a variety of immune-mediated mechanisms (complement-dependent… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Multiple myeloma cells uniformly overexpress CD38. We studied daratumumab, a CD38-targeting, human IgG1κ monoclonal… (More)
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Highly Cited
2015
Highly Cited
2015
Daratumumab (DARA) is a human CD38-specific IgG1 antibody that is in clinical development for the treatment of multiple myeloma… (More)
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Review
2015
Review
2015
Daratumumab (Darzalex™) is a first-in-class, humanized IgG1κ monoclonal antibody that targets the CD38 epitope and was developed… (More)
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Highly Cited
2011
Highly Cited
2011
CD38, a type II transmembrane glycoprotein highly expressed in hematological malignancies including multiple myeloma (MM… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND In our efforts to develop novel effective treatment regimens for multiple myeloma we evaluated the potential benefits… (More)
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